IRF6 Antibodies

AND IRF6 ELISA kits, IRF6 Proteins

Many biological assays use antibodies to detect IRF6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRF6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRF6 antibodies...

We validate the specificity of these antibodies to IRF6 by testing them on tissues known to express IRF6 positively and negatively. Browse below to find the IRF6 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IRF6 Infographic by Boster Bio

All IRF6 Products

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Product

Figures

Specificity

Applications

Price

Anti-IRF6 Rabbit Monoclonal Antibody

6 Q&As

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M01822
100 μl

Anti-Interferon regulatory factor 6 IRF6 Antibody

Human, Mouse, Rat

$405
Cat # A01822
100ul

Anti-Interferon regulatory factor 6 IRF6 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A01822-1
100ul

Anti-IRF6 Mouse Monoclonal Antibody [Clone ID: OTI2C10]

+11

Dog, Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M01822-1
100 µl

IRF6 (NM_006147) Human Over-expression Lysate

Human

$628
Cat # LS003664
100 µg

IRF6 Overview

Facts about Interferon regulatory factor 6.

IRF6 3D structure. Source: alphafold

Interferon regulatory factor 6 (IRF6)

Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity).

Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).

Gene Information

Human
Gene Name:	IRF6
Uniprot:	O14896
Entrez:	3664

Family

Belongs to:

IRF family

Alternative Names

interferon regulatory factor 6; IRF6; IRF-6; LPS; OFC6; OFC6PPS; PIT; PPS; Van der Woude syndrome; VWS; VWS1

Molecular Weight

Mass (kDA):
53.13 kDA

Genomic Context


Human

Location:	1q32.2
Sequence:	1; NC_000001.11 (209785617..209806175, complement)

Tissue Specificity

Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.

Subcellular Localizations

Nucleus. Cytoplasm. Translocates to nucleus in response to an activating signal.

Diseases

Cleft Palate
Cleft Lip
Van Der Woude Syndrome
Congenital Abnormality
Cleft Palate With Cleft Lip
Pterygium
Dysequilibrium Syndrome
Popliteal Pterygium Syndrome
Multiple Pterygium Syndrome
Malignant Neoplasms
Neoplasms
Hypodontia

Developmental Absence Of Tooth
Congenital Absence
Haploinsufficiency
Dysplasia
Ectodermal Dysplasia
Craniofacial Abnormalities
Tissue Adhesions

Interacting Proteins

IRF8

Pathways

Cell Cycle
Pathogenesis
Localization
Translation
Cell Differentiation
Epithelial Cell Differentiation
Cell Adhesion
Developmental Process
Immune Response
Mammary Gland Development
Keratinocyte Differentiation
Palate Development
Gastrulation

Gland Development
Transport
Mammary Gland Morphogenesis
Fertilization
Biosynthetic Process
Epiboly
Cell Cycle Arrest

PTMs

Phosphorylation

Methylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRF6

References

PMID: 16049006 by Bailey C.M., et al. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership.

PMID: 18212048 by Bailey C.M., et al. Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner.