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- Table of Contents
Facts about Platelet-derived growth factor D.
Plays an essential role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis (By similarity).
Rat | |
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Gene Name: | Pdgfd |
Uniprot: | Q9EQT1 |
Entrez: | 66018 |
Belongs to: |
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PDGF/VEGF growth factor family |
IEGFMSTP036; Iris-expressed growth factor; PDGFD; PDGF-D; platelet derived growth factor D; SCDGF-BMGC26867; SCDGFBplatelet-derived growth factor D; spinal cord derived growth factor B; Spinal cord-derived growth factor B; spinal cord-derived growth factor-B
Mass (kDA):
42.809 kDA
Rat | |
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Location: | 8q11 |
Sequence: | 8; |
Widely expressed. Expressed at high levels in the kidney, adrenal glands, eye and CNS. In the kidney the localization is confined to arterial and arteriolar vascular smooth muscle cells and is also detected at low levels in the glomeruli In the eye in the anterior segment it is localized to the iris and ciliary body. In the retina localizes intensely to the outer plexiform layer, which contains photoreceptor axons and the synaptic layer between photoreceptors and second order neurons. In the spinal cord, prominently expressed in the motorneurons.
PMID: 11162582 by Hamada T., et al. Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein.
PMID: 11850188 by Hamada T., et al. The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system.