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PYDC2 Antibodies

AND PYDC2 ELISA kits, PYDC2 Proteins

Many biological assays use antibodies to detect PYDC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PYDC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PYDC2 antibodies...

We validate the specificity of these antibodies to PYDC2 by testing them on tissues known to express PYDC2 positively and negatively. Browse below to find the PYDC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PYDC2 Infographic by Boster Bio

PYDC2 protein infographic

All PYDC2 Products

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Product

Figures

Specificity

Applications

Price

PYDC2 (NM_001083308) Human Recombinant Protein

$1249
Cat # PROTQ56P42
20 µg

PYDC2 (NM_001083308) Human Over-expression Lysate

Human

$628
Cat # LS152138
100 µg

PYDC2 Overview

Facts about Pyrin domain-containing protein 2.

PYDC2 3D structure

PYDC2 3D structure. Source: alphafold

Pyrin domain-containing protein 2 (PYDC2)

May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464).

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Gene Information

Human
Gene Name:	PYDC2
Uniprot:	Q56P42
Entrez:	152138

Gene Information

Family

Belongs to:

No superfamily

Family

Alternative Names

Pyrin domain-containing protein 2

Molecular Weight

Mass (kDA):
10.795 kDA

Molecular Weight

Genomic Context


Human

Location:	3q28
Sequence:	3; NC_000003.12 (191461163..191461456)

Tissue Specificity

Predominantly expressed in peripheral blood. Weakly expressed in testis.

Subcellular Localizations

Cytoplasm. Nucleus. Recruited to specks formed by PYCARD within the cytoplasm.

Subcellular Localization

Interacting Proteins

NLRP2
PYCARD

Interacting Proteins

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PYDC2

References

PMID: 17339483 by Bedoya F., et al. Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions.

PMID: 17178784 by Dorfleutner A., et al. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.