PYDC1 Antibodies

AND PYDC1 ELISA kits, PYDC1 Proteins

Many biological assays use antibodies to detect PYDC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PYDC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PYDC1 antibodies...

We validate the specificity of these antibodies to PYDC1 by testing them on tissues known to express PYDC1 positively and negatively. Browse below to find the PYDC1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PYDC1 Infographic by Boster Bio

All PYDC1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ASC2 (ASC-2/POP) PYDC1 Antibody

5 Q&As

Human, Mouse, Rat

IP, IHC, WB

$328
Cat # A11388
50 µl

ASC2 (PYDC1) (NM_152901) Human Recombinant Protein

$1062
Cat # PROTQ8WXC3
20 µg

Anti-ASC2 (PYDC1) Mouse Monoclonal Antibody [Clone ID: OTI9C10]

Human

IHC, WB

$523
Cat # M11388
100 µl

ASC2 (PYDC1) (NM_152901) Human Over-expression Lysate

Human

$628
Cat # LS260434
100 µg

PYDC1 Overview

Facts about Pyrin domain-containing protein 1.

PYDC1 3D structure. Source: alphafold

Pyrin domain-containing protein 1 (PYDC1)

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation.
Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Gene Information

Human
Gene Name:	PYDC1
Uniprot:	Q8WXC3
Entrez:	260434

Family

Belongs to:

No superfamily

Alternative Names

ASC2PAAD-only protein 1; ASCI; POP1pyrin domain-containing protein 1; PYC1; PYD (pyrin domain) containing 1; pyrin domain containing 1; pyrin-domain containing protein 1; Pyrin-only protein 1

Molecular Weight

Mass (kDA):
10.107 kDA

Genomic Context


Human

Location:	16p11.2
Sequence:	16; NC_000016.10 (31215962..31217135, complement)

Tissue Specificity

Predominantly expressed in monocytes, macrophages and granulocytes.

Subcellular Localizations

Cytoplasm. Recruited to specks formed by PYCARD within the cytoplasm.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PYDC1

References

PMID: 11786556 by Manji G.A., et al. PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB.

PMID: 12656673 by Stehlik C., et al. The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.