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- Table of Contents
Facts about TIP41-like protein.
The PP2A(C):TIPRL complex doesn't show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is suggested to implicate it in DNA damage response by boosting H2AFX phosphorylated on Ser-140 (gamma-H2AFX).
Mouse | |
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Gene Name: | Tiprl |
Uniprot: | Q8BH58 |
Entrez: | 226591 |
Belongs to: |
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TIP41 family |
dJ69E11.3; MGC3794; putative MAPK activating protein; Putative MAPK-activating protein PM10; TIP41, TOR signaling pathway regulator-like (S. cerevisiae); TIP41-like protein; TIP41Type 2A-interacting protein; TIPTIP41, TOR signalling pathway regulator-like (S. cerevisiae)
Mass (kDA):
31.254 kDA
Mouse | |
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Location: | 1|1 H2.2 |
Sequence: | 1; |
PMID: 26717153 by Rosales K.R., et al. TIPRL inhibits protein phosphatase 4 activity and promotes H2AX phosphorylation in the DNA damage response.