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Protein-tyrosine kinase 6 Antibodies
AND PTK6 ELISA kits, Protein-tyrosine kinase 6 Proteins
Many biological assays use antibodies to detect Protein-tyrosine kinase 6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein-tyrosine kinase 6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein-tyrosine kinase 6 antibodies...
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PTK6 Infographic by Boster Bio
All PTK6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1067
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1067
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2193
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2193
1 kit, containing two 96-well plates and all necessary reagents
PTK6 Overview
Facts about Protein-tyrosine kinase 6.
Protein-tyrosine kinase 6 (PTK6)
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization.
A number of potential nuclear and cytoplasmic substrates have been identified. Associates also with a variety of proteins which are likely upstream of PTK6 in various signaling pathways, or for which PTK6 can play an adapter-like role.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTK6 |
| Uniprot: | Q13882 |
| Entrez: | 5753 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Breast tumor kinase; Brk; BRKprotein-tyrosine kinase 6; EC 2.7.10; EC 2.7.10.2; FLJ42088; protein-tyrosine kinase BRK; PTK6 protein tyrosine kinase 6; PTK6; Sik; Tksk; Tyrosine-protein kinase BRK
Molecular Weight
Mass (kDA):
51.834 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.33 |
| Sequence: | 20; NC_000020.11 (63528001..63537376, complement) |
Tissue Specificity
Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines.
Subcellular Localizations
Cytoplasm. Nucleus. Cell projection, ruffle. Membrane. Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
Diseases
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Tumor Progression
- Malignant Paraganglionic Neoplasm
- Colonic Neoplasms
- Cell Invasion
- Melanoma
Interacting Proteins
- EFHC2
- ERBB2
- EXOC5
- FCHO1
- GAB1
- KHDRBS2
- KIT
- REL
- SFPQ
- WASL
Pathways
- Localization
- Cell Proliferation
- Cell Migration
- Cell Cycle
- Oncogenesis
- Cell Growth
- Rna Interference
- Nuclear Export
- Cell Differentiation
- Transport
- Reverse Transcription
- Epithelial Cell Differentiation
- Induction Of Apoptosis
PTMs
- Phosphorylation
- Methylation
- Myristoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTK6
bosterbio.com/bosterbio-gene-info-cards/PTK6
References
PMID: 8036022 by Mitchell P.J., et al. Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours.
PMID: 9333026 by Mitchell P.J., et al. Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk.