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- Table of Contents
Facts about Prostaglandin E synthase 2.
Human | |
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Gene Name: | PTGES2 |
Uniprot: | Q9H7Z7 |
Entrez: | 80142 |
Belongs to: |
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GST superfamily |
C9orf15; chromosome 9 open reading frame 15; EC 5.3.99.3; FLJ14038; gamma-interferon-activated transcriptional element-binding factor 1; GATE-binding factor 1; GBF1; membrane-associated prostaglandin E synthase 2; Microsomal prostaglandin E synthase 2; microsomal prostaglandin E synthase-2; mPGES2; mPGES-2; PGES2; PGES2MGC11289; prostaglandin E synthase 2; PTGES2
Mass (kDA):
41.943 kDA
Human | |
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Location: | 9q34.11 |
Sequence: | 9; NC_000009.12 (128120693..128128462, complement) |
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
Golgi apparatus membrane; Single-pass membrane protein.; [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region. Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.
PMID: 11866447 by Tanikawa N., et al. Identification and characterization of a novel type of membrane- associated prostaglandin E synthase.
PMID: 12804604 by Watanabe K., et al. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2.