PTGES2 Antibodies

Prostaglandin E synthase 2 (PTGES2)

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). .

Gene Information

Human
Gene Name:	PTGES2
Uniprot:	Q9H7Z7
Entrez:	80142

Family

Belongs to:
GST superfamily

Alternative Names

C9orf15; chromosome 9 open reading frame 15; EC 5.3.99.3; FLJ14038; gamma-interferon-activated transcriptional element-binding factor 1; GATE-binding factor 1; GBF1; membrane-associated prostaglandin E synthase 2; Microsomal prostaglandin E synthase 2; microsomal prostaglandin E synthase-2; mPGES2; mPGES-2; PGES2; PGES2MGC11289; prostaglandin E synthase 2; PTGES2

Molecular Weight

Mass (kDA):
41.943 kDA

Genomic Context

Human
Location:	9q34.11
Sequence:	9; NC_000009.12 (128120693..128128462, complement)

Tissue Specificity

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

Subcellular Localizations

Golgi apparatus membrane; Single-pass membrane protein.; [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region. Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.

Diseases

• Malignant Neoplasms
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Endometrial Polyp
• Neoplasms
• Adenocarcinoma
• Obesity
• Malignant Neoplasm Of Breast
• Choline Deficiency
• Endometrial Adenocarcinoma
• Endometrial Neoplasms
• Hypoxia

• Sequelae Aspects
• Tumor Angiogenesis
• Metabolic Syndrome X
• Impaired Glucose Tolerance
• Anoxia
• Dysequilibrium Syndrome

Interacting Proteins

• C1orf189

Pathways

• Methylation
• Decidualization
• Cell Proliferation
• Parturition
• Fertilization
• Dna Methylation
• Angiogenesis
• Pathogenesis

• Meiosis
• Localization
• Secretion

PTMs

• Cleavage

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTGES2

Best Uses Of The PTGES2 Marker

The PTGES2 Marker has several benefits. For instance, this antibody has high affinity to human and mouse proteins, and has anti-inflammatory/immunosuppressive properties against different immune cells. So, how do you use this antibody? Let's look at some of the most effective uses of this antibody. This article will also provide information on some of the most popular types of antibody and their functions.

PTGES2 Marker

The PTGES2 marker may be a type III transmembrane-protein. It is composed a 57 Aa luminal area, a 17 Aa transmembrane segments, and a 300-Aa cytoplasmicdomain containing a GST like region. The human protein has two alternative splice forms, a 19-aa insertion after Ser159, and an alternate start site at Met192. The sequence identity of the human and mouse PTGES2 proteins is 91%.

There are many benefits to using the PTGES/PGE2 marker for targeting tumor cells. It reduces MDSC recruitment and boosts T-cell immunity. This is important for suppressing lung metastasis among Gprc5a/ko mice. The protein can detect cancer cells in vivo, and help determine if a patient's tumor has progressed or not.

Cancer cells are able to resist cytotoxic-T-cells by using PTGES/PGE2 Signaling. Two important roles play PTGES/PGE2 in lung metastatic disease. It confers resistance to T-cell cytotoxicity by polarizing M2 macrophages and enhances MDSC recruitment. Furthermore, PTGES/PGE2 signaling also suppresses lung metastasis in Gprc5a-ko mice.

Low levels of PTGES2 in lung cancer cells can predict poor overall survival. Similarly, high levels of GPRC5A and PTGES are associated with lung inflammation. However, both GPRC5A- and PTGES expressions can be used to detect lung cancer cells. They are also related. These findings can provide clues to future treatments. More research is needed. This marker could have many uses and should therefore be used in clinical settings.

Primary antibodies with high affinity

Monoclonal antibodies from mice that recognize PTGES2 or its ligand, PTGES2, are used to generate high-affinity primary antibodies. The PTGES2 ligand is well-known, but its function in humans has not been determined. This marker is used to measure MPGES-2 function in this study. MPGES-2 (a marker of B-cells) is involved in glucose metabolism.

The Caco-2 human colon epithelial cells were transfected with SARS-CoV-2 virus at a multiplicity of 0.1. After transfection, cells received SARS-CoV-2 virus were given to Caco-2 human colon epithelial cells. They were then washed twice with PBS. Cells were then left to rest for 20 minutes in 4% paraformaldehyde and PBS at room temperature. The cell lysates then were cooled in 0.01 M glycine over 5 minutes. They were then visualized using a Confocal Laser Scanning Microscope.

Immunosuppressive/anti-inflammatory effects on various immune cells

We previously reported that the PTGES2 marker found in Boster Bio mice exhibits immunosuppressive/anti-inflammatory effects in various immune cells. It is still not clear how this PTGES2 peptide influences the immune response of human patients. This possibility was explored by studying the PTGES2 protein within various immune cells.