PTGER4 Antibodies

Prostaglandin E2 receptor EP4 subtype (PTGER4)

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase.

Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Gene Information

Human
Gene Name:	PTGER4
Uniprot:	P35408
Entrez:	5734

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

EP4; EP4R; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER2; PTGER4

Molecular Weight

Mass (kDA):
53.119 kDA

Genomic Context

Human
Location:	5p13.1
Sequence:	5; NC_000005.10 (40679915..40740936)

Tissue Specificity

High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

• Mycoplasma Pneumonia
• Inflammation
• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Arthritis
• Rheumatoid Arthritis
• Neoplasm Metastasis
• Ulcer
• Colitis
• Inflammatory Bowel Diseases
• Tissue Adhesions
• Malignant Neoplasm Of Breast

• Carcinogenesis
• Tumor Angiogenesis
• Intestinal Diseases
• Mammary Neoplasms
• Colorectal Cancer
• Cell Invasion
• Pain

Pathways

• Secretion
• Pathogenesis
• Cell Proliferation
• Localization
• Bone Resorption
• Cytokine Production
• Angiogenesis
• Cell Growth
• Immune Response
• Parturition
• Cell Migration
• Inflammatory Response
• Ovulation

• Luteolysis
• Cell Cycle
• Sensitization
• Vasoconstriction
• Regeneration
• Transport
• Osteoblast Differentiation

PTMs

• Phosphorylation
• Demethylation
• Reduction

• Methylation
• Dephosphorylation
• Oxidation

• Ubiquitination

Research Areas

• Cancer
• GPCR
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTGER4

Best Uses of the PTGER4 Marker and Anti-Prostaglandin E Receptor EP4 Antibody Picoband

You've come to a good spot if you're interested in the PTGER4 marker and Anti-Prostaglandin Ep4/PTGER4 Antibody Picoband. In this article, we'll go over its advantages and its applications. This article will help you make the most of this tool. Find out more! These are the top three reasons why you need to use this product.

Marker PTGER4

A decision tree combining stature genebox 2 gene (SHOX2) together with prostaglandin E receptor 4 (4 (PTGER4) methylation levels and other traditional tumor markers (such as PTGER4) was recently created. The tree is able to identify patients with lung cancer and helps differentiate between malignant and benign lung nodules. This decision tree is currently available in Japan. Additional data from other institutions will be required to verify its validity.

A decreased activity of Ptger4 in DLBCL, which is a type of lymphoma that is responsible for 30-40% of all lymphomas in humans and mice, can result in poor prognosis. In mouse models, PTGER4 knockout decreases arthritis symptoms. Studies of mice infected with collagen antibodies demonstrated that arthritis-related symptoms are reduced when there is a lack of Ptger4. Additionally, PTGER4 along with its variant rs10440635 are linked with ankylosing spondylitis. the gene copy numbers of rs10440635 has been linked to inflammatory bowel disease.

A new genetic variant identified in the PTGER4 gene has been associated with an increased risk of developing rheumatoid arthritis. Although there is no definitive connection has been identified with an PTGER4 polymorphism however the result is still hopeful. This variant is associated with an increased risk of developing early rheumatoidarthritis in people of all races and ethnicities. However, further investigation is required to discover its role in early forms of the disease and its impact on physical function.

Anti-Prostaglandin E Receptor EP4/PTGER4 Antibody Picoband

The anti-Prostaglandin E Recepts (Ptgers) is part of the Picoband(tm) antibody catalog. It reacts with Human Prostaglandin E Receptor EP4 protein. Antibodies against this gene are stable at -20°C for up to one year. These antibodies are made from mouse sequences. They can be stored for long periods at -20degC.

This monoclonal antibody recognizes the PTGER4 which is a PGE2-receptor. It stops the reorganization of cytoskeletons, and helps in the healing of microvascular monolayers of endothelial cells in the lungs. Additionally this antibody blocks adhesion of neutrophils, and blocks their migration.

Applications

We evaluated the methylated PTGER4 marker to evaluate the therapeutic response and overall survival rate of patients suffering from NSCLC. It demonstrated better predictive power compared with three clinically-used protein markers (CEA, CA125, and NSE). The results suggested that methylated PTGER4 could serve as a better marker of therapeutic response in the coming years. This marker is sensitive to therapy, but has a limited sensitivity.

The PTGER4 gene is a prostaglandin E-receptor, is found in many tissues. It relaxes smooth muscles and may play a significant role in renal hemodynamics and intestinal epithelial transport. ESTs of the PTGER4 gene were extracted from a variety of human tissue libraries. We also performed a quantitative analysis to estimate PTGER4 methylation.

The PTGER4 gene is methylated during lung cancer. The marker mPTGER4 has been used in lung cancer research as a differential diagnosis for benign and malignant disorders. The test's sensitivity and specificity was enhanced by the mPTGER4 genes in conjunction with the the mSHOX2 genes. These results have significant clinical implications for lung cancer diagnosis. This study will help doctors identify patients with advanced stage lung cancer.

The methylated PTGER4 marker predicts overall survival in stage IV non-small-cell lung cancer. Researchers employed a mix of both markers to study changes in each marker during treatment. To assess the response and intensity to treatment, methylated protein PTGER4 was more sensitive than the proteins markers. It also shows changes in the levels of ctDNA in plasma, which indicate the release of cell DNA during apoptosis. Thus, the mPTGER4 could be an ad hoc biomarker that is more sensitive in the long-term evaluation of the efficacy of treatment.

Benefits

The PTGER4 marker has been created to detect lung cancer in patients with circulating DNA. The marker is able to differentiate lung cancer patients from healthy controls by detecting changes in the prostaglandin E receptor 4 gene. Patients' plasma samples are taken to obtain DNA that is present in the bloodstream. The marker is very specific and sensitive. It can detect early stage lung carcinoma in patients at high risk for developing lung cancer.

Both Csf1r/Ptger4 and WT mice carry the PTGER4 gene. Knockout mice have lower crypt numbers in mice suffering from UC or ulcerative colitis than WT. Additionally, the mice that do not have the PTGER4 gene have fewer Ki67+ proliferating cells than WT mice. The WT mice had significantly more crypts after 7 days of treatment, while mice with the knockout gene had significantly fewer.