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PSTPIP1 Antibodies
AND PSTPIP1 ELISA kits, PSTPIP1 Proteins
Many biological assays use antibodies to detect PSTPIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSTPIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSTPIP1 antibodies...
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PSTPIP1 Infographic by Boster Bio
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PSTPIP1 Overview
Facts about Proline-serine-threonine phosphatase-interacting protein 1.
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)
Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity.
Bridges the interaction between ABL1 and PTPN18 Resulting in ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSTPIP1 |
| Uniprot: | O43586 |
| Entrez: | 9051 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD2BP1CD2-binding protein 1; CD2BP1L; CD2BP1S; H-PIPPEST phosphatase-interacting protein 1; PAPASCD2 antigen-binding protein 1; proline-serine-threonine phosphatase interacting protein 1; proline-serine-threonine phosphatase-interacting protein 1; PSTPIPCD2 cytoplasmic tail-binding protein
Molecular Weight
Mass (kDA):
47.591 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q24.3 |
| Sequence: | 15; NC_000015.10 (76994680..77037475) |
Tissue Specificity
Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta.
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, uropodium. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cleavage furrow. Mainly cytoplasmic in T-cells (PubMed:9857189). Colocalizes in cluster with CD2 near the cell surface membrane in activated T-cells (PubMed:9857189). In monocytes, forms a branched filamentous network in the cytoplasm (PubMed:19584923). In transfected cells, forms relatively straight filaments radiating out from the nucleus (PubMed:19584923). Filament formation requires an intact tubulin cytoskeleton (PubMed:
Diseases
- Pyoderma Gangrenosum
- Pyoderma
- Acne
- Arthritis
- Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
- Familial Mediterranean Fever
- Inflammation
- Brucellosis
- Arthritis, Bacterial
- Autoimmune Diseases
- Wiskott-aldrich Syndrome
- Posttransfusion Purpura
Interacting Proteins
- AXIN1
- BUB3
- FAM90A1
- FASLG
- LSM4
- MEFV
- PCDHB14
- PRPF31
- PTPN12
- PTPN18
Pathways
- Cell Activation
- T Cell Activation
- Cytokinesis
- Immune Response
- Innate Immune Response
- Endocytosis
- Pathogenesis
- Cell Adhesion
- Hyperphosphorylation
- Cell Migration
- Platelet Aggregation
- Immunological Synapse Formation
- Inflammatory Response
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSTPIP1
bosterbio.com/bosterbio-gene-info-cards/PSTPIP1
References
PMID: 9857189 by Li J., et al. A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.
PMID: 14595024 by Shoham N.G., et al. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.