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- Table of Contents
Facts about Retinoic acid-induced protein 3.
This retinoic acid-inducible GPCR provide evidence for a potential interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity).
Human | |
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Gene Name: | GPRC5A |
Uniprot: | Q8NFJ5 |
Entrez: | 9052 |
Belongs to: |
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G-protein coupled receptor 3 family |
G protein-coupled receptor, family C, group 5, member A; GPCR5A; GPRC5A; Orphan G-protein-coupling receptor PEIG-1; RAI3; RAI3G-protein coupled receptor family C group 5 member A; RAIG1; RAIG1RAIG-1; retinoic acid induced 3; retinoic acid responsive; Retinoic acid-induced gene 1 protein; retinoic acid-induced protein 3
Mass (kDA):
40.251 kDA
Human | |
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Location: | 12p13.1 |
Sequence: | 12; NC_000012.12 (12891562..12917937) |
Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Localized in perinuclear vesicles, probably Golgi-associated vesicles.
PMID: 8832110 by Cafferata E.G., et al. Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells.
PMID: 9857033 by Cheng Y., et al. Molecular cloning and characterization of a novel retinoic acid- inducible gene that encodes a putative G protein-coupled receptor.