Proline-rich protein 7 Antibodies

AND PRR7 ELISA kits, Proline-rich protein 7 Proteins

Many biological assays use antibodies to detect Proline-rich protein 7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proline-rich protein 7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proline-rich protein 7 antibodies...

We validate the specificity of these antibodies to Proline-rich protein 7 by testing them on tissues known to express PRR7 positively and negatively. Browse below to find the PRR7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRR7 Infographic by Boster Bio

All PRR7 Products

Product

Figures

Specificity

Applications

Price

Anti-PRR7 Purified Monoclonal Antibody

Human, Mouse, Rat

ICC, WB

$354
Cat # M13414
0.1 mg

PRR7 (NM_030567) Human Over-expression Lysate

Human

$628
Cat # LS080758
100 µg

PRR7 Overview

Facts about Proline-rich protein 7.

PRR7 3D structure. Source: alphafold

Proline-rich protein 7 (PRR7)

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189).

Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might encourage apoptosis in T cells (PubMed:21460222).

Gene Information

Human
Gene Name:	PRR7
Uniprot:	Q8TB68
Entrez:	80758

Family

Belongs to:

No superfamily

Alternative Names

MGC10772; proline rich 7 (synaptic); proline-rich protein 7; Synaptic proline-rich membrane protein

Molecular Weight

Mass (kDA):
30.93 kDA

Genomic Context


Human

Location:	5q35.3
Sequence:	5; NC_000005.10 (177445995..177456701)

Tissue Specificity

Strongly expressed in brain tissue including the hippocampus, and moderately expressed in esophagus, trachea, lung, ovary, cervix, prostate, testes, thyroid, thymus, lymph nodes and peripheral blood lymphocytes.

Subcellular Localizations

Cell membrane; Single-pass type III membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type III membrane protein. Cell junction, synapse, postsynaptic density membrane. Cytoplasm, perinuclear region. Cell junction, synapse. Cell projection, dendrite. Nucleus. Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity).

Diseases

Cardiac Arrhythmia
Exhaustion
Blind Vision
Physiological Stress

Pathways

Circadian Rhythm
Photomorphogenesis
De-etiolation
Synapse Maturation
Tricarboxylic Acid Cycle
Lateral Root Formation
Shade Avoidance
Proteolysis
Photoperiodism
Hypersensitivity

Mrna Splicing
Response To Red Light
Response To Cold
Mrna Processing
Cold Acclimation

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRR7

References

PMID: 21460222 by Hrdinka M., et al. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis.

PMID: 27458189 by Kravchick D.O., et al. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.