Proline-rich protein 14 Antibodies

AND PRR14 ELISA kits, Proline-rich protein 14 Proteins

Many biological assays use antibodies to detect Proline-rich protein 14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proline-rich protein 14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proline-rich protein 14 antibodies...

We validate the specificity of these antibodies to Proline-rich protein 14 by testing them on tissues known to express PRR14 positively and negatively. Browse below to find the PRR14 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRR14 Infographic by Boster Bio

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PRR14 (NM_024031) Human Over-expression Lysate

Human

$628
Cat # LS078994
100 µg

PRR14 Overview

Facts about Proline-rich protein 14.

PRR14 3D structure. Source: alphafold

Proline-rich protein 14 (PRR14)

Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742).

Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of this PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574).

Gene Information

Human
Gene Name:	PRR14
Uniprot:	Q9BWN1
Entrez:	78994

Family

Belongs to:

No superfamily

Alternative Names

DKFZp781A13198; MGC3121; proline rich 14; proline-rich protein 14

Molecular Weight

Mass (kDA):
64.328 kDA

Genomic Context


Human

Location:	16p11.2
Sequence:	16; NC_000016.10 (30650778..30656440)

Subcellular Localizations

Chromosome. Nucleus. Nucleus lamina. Nucleus, nucleoplasm. During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase.

Interacting Proteins

CBX3
CBX5

Pathways

Metaphase

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRR14

References

PMID: 24209742 by Poleshko A., et al. The human protein PRR14 tethers heterochromatin to the nuclear lamina during interphase and mitotic exit.

PMID: 25906157 by Yang M., et al. A novel role of PRR14 in the regulation of skeletal myogenesis.