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- Table of Contents
1 Citations 1 Q&As
1 Citations
5 Citations 6 Q&As
1 Citations 2 Q&As
Facts about Prokineticin-1.
Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma development by promoting the proliferation and migration of neuroblastoma cells.
Human | |
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Gene Name: | PROK1 |
Uniprot: | P58294 |
Entrez: | 84432 |
Belongs to: |
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AVIT (prokineticin) family |
EGVEGF; EG-VEGF; EGVEGFblack mamba toxin-related protein; Endocrine-gland-derived vascular endothelial growth factor; Mambakine; PK1mambakine; PRK1prokineticin-1; PROK1; Prokineticin 1
Mass (kDA):
11.715 kDA
Human | |
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Location: | 1p13.3 |
Sequence: | 1; NC_000001.11 (110451149..110457358) |
Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.
Secreted.
PMID: 11259612 by Li M., et al. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.
PMID: 11528470 by LeCouter J., et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium.
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