CARD11 Antibodies

AND CARD11 ELISA kits, CARD11 Proteins

Many biological assays use antibodies to detect CARD11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CARD11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CARD11 antibodies...

We validate the specificity of these antibodies to CARD11 by testing them on tissues known to express CARD11 positively and negatively. Browse below to find the CARD11 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CARD11 Infographic by Boster Bio

All CARD11 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CARMA1 CARD11 Antibody

Human, Mouse

ELISA, IF, IHC-P, WB

$449
Cat # A00740
0.1 mg

Anti-CARD11 (M12) Antibody

Human, Rat

$405
Cat # A00740-1
100ul

Anti-CARD11 Rabbit Monoclonal Antibody

Human, Mouse

IF, ICC, WB

$370
Cat # M00740
100 μl/vial

CARD11 (NM_032415) Human Over-expression Lysate

Human

$628
Cat # LS084433
100 µg

CARD11 Overview

Facts about Caspase recruitment domain-containing protein 11.

CARD11 3D structure. Source: alphafold

Caspase recruitment domain-containing protein 11 (CARD11)

Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.

Activates NF-kappa-B through BCL10 and IKK. Stimulates the phosphorylation of BCL10.

Gene Information

Human
Gene Name:	CARD11
Uniprot:	Q9BXL7
Entrez:	84433

Family

Belongs to:

No superfamily

Alternative Names

BIMP3; BIMP3card-maguk protein 1; CARD11; CARD-containing MAGUK protein 1; Carma 1; CARMA1; CARMA1bcl10-interacting maguk protein 3; caspase recruitment domain family, member 11; caspase recruitment domain-containing protein 11; MGC133069

Molecular Weight

Mass (kDA):
133.284 kDA

Genomic Context


Human

Location:	7p22.2
Sequence:	7; NC_000007.14 (2906075..3043867, complement)

Tissue Specificity

Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.

Subcellular Localizations

Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.

Diseases

Lymphoma
B-cell Lymphomas
Diffuse Large B-cell Lymphoma
Neoplasms
Malignant Neoplasms
Marginal Zone B-cell Lymphoma
Mucosa-associated Lymphoid Tissue Lymphoma
Immunologic Deficiency Syndromes
Leukemogenesis
Inflammation
Autoimmune Diseases
Cell Transformation, Neoplastic
Leukemia

Autoimmunity
Central Nervous System Neoplasms
Malignant Paraganglionic Neoplasm
Multiple Myeloma
Dermatitis
Primary Central Nervous System Lymphoma
Respiratory Hypersensitivity

Interacting Proteins

BCL10
CSNK1A1
MALT1
Map4k1
PRKCD

Pathways

Cell Activation
T Cell Activation
Lymphocyte Activation
Cytokine Production
Pathogenesis
Immune Response
Adaptive Immune Response
Cell Proliferation
Cell Death
Rna Interference
Cell Development
Lymphocyte Proliferation
B Cell Proliferation

T Cell Costimulation
Cell Cycle
Methylation
Cell Growth
Proteolysis
Cell Differentiation
Localization

PTMs

Phosphorylation
Ubiquitination
Methylation

Cleavage
Dephosphorylation
Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CARD11

References

PMID: 11278692 by Bertin J., et al. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB.

PMID: 11356195 by Gaide O., et al. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.