Protein arginine N-methyltransferase 8 (PRMT8)

S-adenosyl-L-methionine-dependent and membrane- associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Willing to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it interacts with completely methylated EWS (PubMed:18320585).

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