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PRMT6 Antibodies
AND PRMT6 ELISA kits, PRMT6 Proteins
Many biological assays use antibodies to detect PRMT6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRMT6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRMT6 antibodies...
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PRMT6 Overview
Facts about Protein arginine N-methyltransferase 6.
Protein arginine N-methyltransferase 6 (PRMT6)
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Preferentially methylates arginyl residues within a glycine and arginine-rich domain and displays taste for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910).
Specifically mediates the asymmetric dimethylation of histone H3'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460).
Gene Information
| Human | |
|---|---|
| Gene Name: | PRMT6 |
| Uniprot: | Q96LA8 |
| Entrez: | 55170 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
EC 2.1.1.-; EC 2.1.1.125; FLJ10559; FLJ51477; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae); HMT1 hnRNP methyltransferase-like 6; HRMT1L6; protein arginine methyltransferase 6; protein arginine N-methyltransferase 6
Molecular Weight
Mass (kDA):
41.938 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.3 |
| Sequence: | 1; NC_000001.11 (107056674..107059294) |
Tissue Specificity
Highly expressed in kidney and testis.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Immunologic Deficiency Syndromes
- Hiv Infections
- Malignant Neoplasm Of Breast
- Mastitis-metritis-agalactia Syndrome
- Non-neoplastic Disorder
- Tumor Progression
- Malignant Neoplasm Of Lung
- Osteosarcoma
- Bladder Neoplasm
- Lung Neoplasms
Interacting Proteins
- C8orf74
- CDCA4
- DNAJA3
- DNALI1
- FYCO1
- GRHL3
- GSTCD
- GTPBP2
- HESX1
- HMGA2
Pathways
- Methylation
- Cell Cycle
- Dna Repair
- Senescence
- Cell Proliferation
- Localization
- Rna Processing
- Cellular Senescence
- Cell Cycle Arrest
- Cell Division
- Chromatin Remodeling
- Pathogenesis
- Viral Replication
PTMs
- Methylation
- Phosphorylation
Research Areas
- Chromatin Research
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRMT6
bosterbio.com/bosterbio-gene-info-cards/PRMT6
References
PMID: 11724789 by Frankel A., et al. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.
PMID: 15334060 by Singh V., et al. DAL-1/4.1B tumor suppressor interacts with protein arginine N- methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.