Protein kinase C eta type Antibodies

Protein kinase C eta type (PRKCH)

Calcium-independent, phospholipid- and diacylglycerol (DAG)-reliant serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation.

Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, resulting in RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation.

Gene Information

Human
Gene Name:	PRKCH
Uniprot:	P24723
Entrez:	5583

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.13; nPKC-eta; PKCLMGC26269; PKC-LMGC5363; PRKCLprotein kinase C eta type; protein kinase C, eta

Molecular Weight

Mass (kDA):
77.828 kDA

Genomic Context

Human
Location:	14q23.1
Sequence:	14; NC_000014.9 (61187305..61550980)

Tissue Specificity

Most abundant in lung, less in heart and skin.

Subcellular Localizations

Cytoplasm.

Diseases

• Cerebrovascular Accident
• Infarction
• Lacunar Infarction
• Ischemic Stroke
• Hypertensive Disease
• Hemorrhage
• Rheumatoid Arthritis
• Arthritis
• Brain Infarction
• Cerebral Infarction
• Dysequilibrium Syndrome
• Inflammation

• Cerebral Hemorrhage
• Coronary Artery Disease
• Ischemia
• Atherosclerosis
• Diabetes Mellitus
• Autoimmune Reaction
• Stomach Neoplasms

Pathways

• Pathogenesis
• Aging
• Methylation
• Dna Hypomethylation
• Dna Methylation

PTMs

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKCH

Boster Bio - Best Uses Of The PRKCH Marker

You might have heard of the Boster Bio Picokine ELISA system. But do you really know the benefits of using Picoband? Picoband can help you discover the benefits. Don't forget about custom services and BeNeLux deliveries. This article will discuss how Boster Bio's Picoband could benefit your research.

Boster Bio's Picokine ELISA-platform

Picokine(tm), ELISA platforms, are designed to increase sensitivity to the picogram-level and provide rapid results. Picokine ELISA tests can be validated with multiple specimens and can also be ordered on request. ELISA kit with Supervision secondary antibodies takes about 30 minutes to perform IHC. These kits are backed by technical support from BeNeLux distributor Sanbio.

PicoKine(tm), ELISA kits validate by reducing non-specific binding, and increasing the binding effectiveness of capture antibodies. This results in high specificity and low background, as well as single-digit picogram level sensitivities. They are tested at 37 degC for one week before release and are supplied with sufficient reagents for 96 tests. Picokine(tm), ELISA Kits have been validated against a variety sample types and are now available from tebubio.

Boster Bio's Picoband ELISA platform

This high sensitivity ELISA platform improves ELISA sensitivity down to the picogram levels. These kits are compatible with a wide variety of samples. Validation images can be requested. Supervision, a polymer-based secondary antibody, is also included in this new platform. It can save up to 30 minutes IHC staining time. Picoband's design insights are backed by technical support and technical support from Sanbio BeNeLux distributor.

Boster Bio's Picoband

The BosterBio Anti-PKC/PRKCH Antibody, part of the Picoband (tm) series, reacts to Human. The antibody is stable at -20degC one year and fourdegC one month. It contains 5mg BSA, 0.25 mg Na2HPO4 0.05mM NaN3. It shares a 96.1% identical amino acid sequence to the mouse.

The Boster Picokine(tm) platform enables high sensitivity ELISA and IHC testing, enabling sensitivity down to picograms. It has been validated for a wide range of samples and is available on request with the validation images and procedure. Supervision, a secondary antibody made of polymers, is also available. It can save up to thirty minutes of IHC. Picoband, powered by Boster Bio's expertise in immunogen design and supported technical support from Sanbio, its BeNeLux dealer, Sanbio.