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- Table of Contents
Facts about PR domain zinc finger protein 15.
Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions.
Human | |
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Gene Name: | PRDM15 |
Uniprot: | P57071 |
Entrez: | 63977 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
C21orf83; chromosome 21 open reading frame 83; PFM15; PR domain containing 15; PR domain zinc finger protein 15; PR domain-containing protein 15; Zinc finger protein 298; ZNF298
Mass (kDA):
169.269 kDA
Human | |
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Location: | 21q22.3 |
Sequence: | 21; NC_000021.9 (41798225..41879396, complement) |
Detected in all tissues examined.
Nucleus.
PMID: 12036298 by Gardiner K., et al. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.
PMID: 15904895 by Shibuya K., et al. Identification of a novel zinc finger protein gene (ZNF298) in the GAP2 of human chromosome 21q.