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PPP1CB Antibodies
AND PPP1CB ELISA kits, PPP1CB Proteins
Many biological assays use antibodies to detect PPP1CB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP1CB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP1CB antibodies...
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PPP1CB Infographic by Boster Bio
All PPP1CB Products
Product
Figures
Specificity
Applications
Price
Chicken, Human, Mouse, Pig, Rat
WB
$399
Cat # A04022-1
100μl
Cat # A04022-1
100μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04022-1
100 μl/vial
Cat # M04022-1
100 μl/vial
Human
$628
Cat # LS005500
100 µg
Cat # LS005500
100 µg
PPP1CB Overview
Facts about Serine/threonine-protein phosphatase PP1-beta catalytic subunit.
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)
Protein phosphatase that associates with over 200 regulatory proteins to produce highly specific holoenzymes that dephosphorylate countless biological targets. Involved in regulation of ionic conductances and long-term synaptic plasticity.
Part of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. According to CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the rate and rhythmicity of PER1 and PER2 phosphorylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPP1CB |
| Uniprot: | P62140 |
| Entrez: | 5500 |
Family
| Belongs to: |
|---|
| PPP phosphatase family |
Alternative Names
EC 3.1.3.16; EC 3.1.3.53; MGC3672; PP1beta; PP-1Bprotein phosphatase 1, catalytic subunit, delta isoform; PPP1CD; protein phosphatase 1, catalytic subunit, beta isoform; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase 1-beta; protein phosphatase 1-delta; serine/threonine protein phosphatase PP1-beta catalytic subunit; serine/threonine-protein phosphatase PP1-beta catalytic subunit
Molecular Weight
Mass (kDA):
37.187 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p23.2 |
| Sequence: | 2; NC_000002.12 (28751748..28802940) |
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Neoplasms
- Malignant Squamous Cell Neoplasm
- Lung Neoplasms
- Carcinoma
- Diabetes Mellitus, Non-insulin-dependent
- Cell Invasion
- Neoplasm Metastasis
- Melanoma
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- ACTN2
- BRCA1
- Clock
- CSRNP2
- PPP1R11
- PPP1R13L
- PPP1R16A
- PPP1R16B
- PPP1R2B
- PPP1R3C
Pathways
- Pathogenesis
- Localization
- Cell Motility
- Cellular Homeostasis
- Insulin Secretion
- Dna Repair
- Metaphase
PTMs
- Phosphorylation
Research Areas
- Cancer
- Lipid and Metabolism
- Protein Phosphatase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP1CB
bosterbio.com/bosterbio-gene-info-cards/PPP1CB
References
PMID: 8312365 by Barker H.M., et al. Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB).
PMID: 7796987 by Prochazka M., et al. Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians.