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PPP1CC Antibodies
AND PPP1CC ELISA kits, PPP1CC Proteins
Many biological assays use antibodies to detect PPP1CC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP1CC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP1CC antibodies...
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PPP1CC Overview
Facts about Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC)
Protein phosphatase that associates with over 200 regulatory proteins to produce highly specific holoenzymes that dephosphorylate countless biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPP1CC |
| Uniprot: | P36873 |
| Entrez: | 5501 |
Family
| Belongs to: |
|---|
| PPP phosphatase family |
Alternative Names
EC 3.1.3.16; PP-1G; PP1gamma; PPP1G; protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase 1C catalytic subunit; serine/threonine phosphatase 1 gamma; serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Molecular Weight
Mass (kDA):
36.984 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.11 |
| Sequence: | 12; NC_000012.12 (110708369..110742914, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeti
Diseases
- Infertility
- Male Infertility
- Azoospermia
- Keratosis Follicularis
- Testicular Hypogonadism
- Thymoma
- Hypoxia
- Spermatogenesis Abnormal
- Teratocarcinoma
- Aneuploidy
- Malignant Neoplasm Of Lung
- Carcinogenesis
Interacting Proteins
- AKAP4
- BRCA1
- CD2BP2
- Clock
- CSRNP1
- CSRNP2
- ESR1
- LMTK2
- NEK2
- OGT
Pathways
- Spermatogenesis
- Sperm Motility
- Localization
- Pachytene
- Meiosis
- Keratinization
- Cell Proliferation
- Blood Vessel Development
- Mitosis
- Fertilization
- Spermatid Development
PTMs
- Phosphorylation
Research Areas
- Cancer
- Lipid and Metabolism
- Protein Phosphatase
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP1CC
bosterbio.com/bosterbio-gene-info-cards/PPP1CC
References
PMID: 8394140 by Barker H.M., et al. Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2.
PMID: 8111128 by Norman S.A., et al. Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA.