PPARGC1B Antibodies

Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)

Plays a part of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids.

May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as indicated by increased cerebral oxygen consumption and mitochondrial amount when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.

Gene Information

Human
Gene Name:	PPARGC1B
Uniprot:	Q86YN6
Entrez:	133522

Family

Belongs to:
No superfamily

Alternative Names

DKFZp686C1790; ERRL1; PERCFLJ14284; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC1; PGC1Bgamma, coactivator 1, beta; PPARGC1

Molecular Weight

Mass (kDA):
113.222 kDA

Genomic Context

Human
Location:	5q32
Sequence:	5; NC_000005.10 (149730302..149857861)

Tissue Specificity

Ubiquitous with higher expression in heart, brain and skeletal muscle.

Subcellular Localizations

Nucleus.

Diseases

• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Obesity
• Insulin Resistance
• Malignant Neoplasms
• Malignant Neoplasm Of Breast
• Neoplasms
• Insulin Sensitivity
• Mammary Neoplasms
• Inflammation
• Cardiomyopathies
• Exhaustion
• Systemic Infection

• Heart Failure
• Metabolic Diseases
• Liver Carcinoma
• Cardiovascular Diseases
• Obesity, Morbid
• Nerve Degeneration
• Mitochondrial Diseases

Pathways

• Oxidative Phosphorylation
• Pathogenesis
• Energy Homeostasis
• Gluconeogenesis
• Glycolysis
• Transport
• Glucose Homeostasis
• Cell Proliferation
• Cell Growth
• Fatty Acid Oxidation
• Osteoclast Differentiation
• Acute Inflammatory Response
• Osteoclast Development

• Tricarboxylic Acid Cycle
• Electron Transport
• Electron Transport Chain
• Aging
• Inflammatory Response
• Mitochondrial Fusion
• Cellular Respiration

PTMs

• Phosphorylation

• Oxidation

• Acetylation

Research Areas

• Lipid and Metabolism
• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPARGC1B

Best Uses Of The PPARGC1B Marker

The PPARGC1B marker offers many benefits. This method is highly specific, allowing you to focus on your original medical or biological objective instead of a plethora of information. It does have its limitations. Find out more about these methods, including their limitations and costs. Get started now to use this marker! There are many ways to use this biomarker.

Limitations

The PPARGC1B gene was first identified in mice by cloning a particular gene. These mice express PPARGC1B more frequently, which is a marker of the gene regulating acyl CoA metabolism. The transgenic mice expressing PPARGC1B also show increased energy expenditure and hyperphagia. These traits could be linked to the development AHR. There are limitations to the PPARGC1B-marker, such as its sensitivity in cancer research and specificity.

Methods

Airway hypersensitivity in asthma can be diagnosed using the PPARGC1B genetic polymorphism. Recently, it has been revealed that the gene's expression is high in certain parts of the body such as the lung. It is not clear how a marker derived PPARGC1B could help diagnose the disease. This article will discuss how to use the PPARGC1B gene marker.

The transcriptional level in PPARGC1B's promoter region is controlled. Although the +102525G>ASNP is not expected affect isoform synthesis, it may affect the binding a transcription factor to that gene. The PPARGC1B Gene is expressed at the transcriptional level in human tissues. Its promoter is located near to the CC gene and may be the binding area for this transcription factor.

Real-time PCR has been used to analyze the polymorphisms in PPARGC1B. Its intercalating dye, SYBR Green I, was used. This intercalating color was used by Russian researchers at Litech. The results showed subjects with the minor variant had significantly lower serum levels of triglycerides. These results suggest a possible association between T2DM and PPARGC1B gene mutations.

The detection of breast tumors can be made easier with the help of the PPARGC1B marker gene expression. This marker has been associated with breast cancer, but the exact mechanism by which it functions in the disease remains unknown. Further research is needed to understand the role of PGC-1b. These studies also show that PGC-1b and FOXA2 can be used in tandem to detect the presence of one or both of these proteins.

Cost

Different health outcomes can result from a PPARGC1B PPARGC1B variant in a human genetic gene. Its polymorphism, 203Pro, is associated with a higher level of aerobic performance among athletes. This polymorphism seems to have an impact on aerobic performance and muscle fiber types. It affects insulin action and protects cells against oxidative stress. It also regulates microvascular flows. It is closely related to genes like the TFAM or LY86 genes. These genes encode proteins that are crucial to the pathophysiology and treatment of inflammation.