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- Table of Contents
Facts about DNA-directed RNA polymerase III subunit RPC4.
Plays a vital role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune reaction.
Human | |
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Gene Name: | POLR3D |
Uniprot: | P05423 |
Entrez: | 661 |
Belongs to: |
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eukaryotic RPC4/POLR3D RNA polymerase subunit family |
BN51 (BHK21) temperature sensitivity complementing; BN51; BN51TDNA-directed RNA polymerase III 47 kDa polypeptide; DNA-directed RNA polymerase III subunit D; DNA-directed RNA polymerase III subunit RPC4; polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; Protein BN51; RNA polymerase III 47 kDa subunit; RNA polymerase III subunit C4; RPC4; RPC53 homolog; temperature sensitive complementation, cell cycle specific, tsBN51; TSBN51RPC53
Mass (kDA):
44.396 kDA
Human | |
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Location: | 8p21.3 |
Sequence: | 8; NC_000008.11 (22245104..22254601) |
Nucleus.
PMID: 3683386 by Ittmann M., et al. Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.
PMID: 12391170 by Hu P., et al. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.