Polr1a Antibodies

AND Polr1a ELISA kits, Polr1a Proteins

Many biological assays use antibodies to detect Polr1a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Polr1a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Polr1a antibodies...

We validate the specificity of these antibodies to Polr1a by testing them on tissues known to express Polr1a positively and negatively. Browse below to find the Polr1a antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Polr1a Infographic by Boster Bio

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Anti-POLR1A Antibody

Human, Mouse, Rat

$405
Cat # A10549
100ul

Polr1a Overview

Facts about DNA-directed RNA polymerase I subunit RPA1.

DNA-directed RNA polymerase I subunit RPA1 (Polr1a)

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors.

Forms the polymerase active center along with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I.

Gene Information

Mouse
Gene Name:	Polr1a
Uniprot:	O35134
Entrez:	20019

Family

Belongs to:

RNA polymerase beta' chain family

Alternative Names

DNA-directed RNA polymerase I subunit RPA1; A190; polymerase (RNA) I polypeptide A, 194kDa; RPA1; RPA194; RPO14; RPO1-4

Molecular Weight

Mass (kDA):
194.11 kDA

Genomic Context


Mouse

Location:	6 C1\|6 32.21 cM
Sequence:	6;

Diseases

Malignant Neoplasms
Neoplasms

Pathways

Ribosome Biogenesis
Rrna Transcription
Methylation
Cell Proliferation
Cell Cycle
Dna Methylation

Cell Growth

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Polr1a

References

PMID: 9236775 by Seither P., et al. Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I.

PMID: 16514417 by Percipalle P., et al. The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.