POLE Antibodies

AND POLE ELISA kits, POLE Proteins

Many biological assays use antibodies to detect POLE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLE antibodies...

We validate the specificity of these antibodies to POLE by testing them on tissues known to express POLE positively and negatively. Browse below to find the POLE antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POLE Infographic by Boster Bio

All POLE Products

Product

Figures

Specificity

Applications

Price

Anti-Myc POLE Antibody

1 Citations

Human, Mouse

IHC

$360
Cat # A00112
100 µl

Anti-POLE1 Antibody

1 Citations 3 Q&As

Human, Rat

ELISA, IHC-P, IF (paraffin)

$335
Cat # A30644
100ul

POLE Overview

Facts about DNA polymerase epsilon catalytic subunit A.

POLE 3D structure. Source: alphafold

DNA polymerase epsilon catalytic subunit A (POLE)

Participates in DNA repair and in chromosomal DNA replication.
.

Gene Information

Human
Gene Name:	POLE
Uniprot:	Q07864
Entrez:	5426

Family

Belongs to:

DNA polymerase type-B family

Alternative Names

DKFZp434F222; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A; EC 2.7.7; EC 2.7.7.7; POLE1FLJ21434; polymerase (DNA directed), epsilon

Molecular Weight

Mass (kDA):
261.518 kDA

Genomic Context


Human

Location:	12q24.33
Sequence:	12; NC_000012.12 (132623758..132687519, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Carcinoma
Colorectal Neoplasms
Malignant Tumor Of Colon
Neoplasms
Colorectal Cancer
Adenocarcinoma
Excessive Daytime Somnolence
Primary Hypersomnia
Lung Neoplasms
Malignant Neoplasm Of Breast
Cataplexy

Microsatellite Instability
Narcolepsy
Sleep Disorders
Malignant Neoplasm Of Lung
Malignant Tumor Of Cervix
Turcot Syndrome (disorder)

Interacting Proteins

POLE2

Pathways

Mismatch Repair
S Phase
Dna Repair
Senescence
Dna Replication
Cell Proliferation
Translesion Synthesis

Pathogenesis

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLE

References

PMID: 8486689 by Kesti T., et al. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.

PMID: 10801849 by Li Y., et al. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.

1 Publications of Boster POLE Antibodies & ELISA Kits

PubMed ID: 23405063, Wang Ph, Gu Zh, Wan Dh, Zhu Wb, Qiu W, Weng Sp, Yu Xq, He Jg. Plos One. 2013;8(2...

*More publications can be found for each product on its corresponding product page