PNPLA2 Antibodies

AND PNPLA2 ELISA kits, PNPLA2 Proteins

Many biological assays use antibodies to detect PNPLA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PNPLA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PNPLA2 antibodies...

We validate the specificity of these antibodies to PNPLA2 by testing them on tissues known to express PNPLA2 positively and negatively. Browse below to find the PNPLA2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PNPLA2 Infographic by Boster Bio

All PNPLA2 Products

Product

Figures

Specificity

Applications

Price

Anti-PNPLA2 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A01800
100ul

Anti-ATGL / PNPLA2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M01800
100 μl/vial

Adipose Triglyceride Lipase (PNPLA2) (NM_020376) Human Over-expression Lysate

Human

$628
Cat # LS057104
100 µg

PNPLA2 Overview

Facts about Patatin-like phospholipase domain-containing protein 2.

PNPLA2 3D structure. Source: alphafold

Patatin-like phospholipase domain-containing protein 2 (PNPLA2)

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity.

May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926).

Gene Information

Human
Gene Name:	PNPLA2
Uniprot:	Q96AD5
Entrez:	57104

Family

Belongs to:

No superfamily

Alternative Names

Adipose triglyceride lipase; ATGL; ATGL1110001C14Rik; Calcium-independent phospholipase A2; Desnutrin; EC 3.1.1.3; FP17548; IPLA2-zeta; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain-containing protein 2; patatin-like phospholipase domain-containing protein 2-like; PEDF R; PEDFR; PEDF-R; Pigment epithelium-derived factor; PNPLA2; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS2; TTS2.2; TTS-2.2; TTS2DKFZp667M109

Molecular Weight

Mass (kDA):
55.316 kDA

Genomic Context


Human

Location:	11p15.5
Sequence:	11; NC_000011.10 (818890..825573)

Tissue Specificity

Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).

Subcellular Localizations

Lipid droplet. Cell membrane; Single-pass type II membrane protein.

Diseases

Obesity
Triglyceride Storage Disease With Ichthyosis
Lipoidosis
Storage Disease
Myopathy
Insulin Resistance
Ichthyoses
Fatty Liver
Insulin Sensitivity
Steatosis
Steatohepatitis
Weakness

Lipid Metabolism Disorders
Diabetes Mellitus
Inflammation
Liver Diseases
Cardiomyopathies
Hereditary Diseases
Muscle Weakness

Pathways

Lipid Storage
Localization
Pathogenesis
Fatty Acid Oxidation
Transport
Gene Silencing
Proteolysis
Menopause
Gluconeogenesis
Energy Homeostasis
Embryo Development

Translation
Regulation Of Cell Shape
Membrane Assembly
Innervation
Triglyceride Homeostasis
Rna Interference

PTMs

Phosphorylation

Oxidation

Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNPLA2

References

PMID: 15550674 by Zimmermann R., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.

PMID: 15364929 by Jenkins C.M., et al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.