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- Table of Contents
Facts about Cysteinyl leukotriene receptor 2.
Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Human | |
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Gene Name: | CYSLTR2 |
Uniprot: | Q9NS75 |
Entrez: | 57105 |
Belongs to: |
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G-protein coupled receptor 1 family |
CysLT(2); CysLT2; CYSLT2KPG_011; CYSLT2RHG57; CysLTR2; cysteinyl leukotriene CysLT2 receptor; Cysteinyl Leukotriene R2; cysteinyl leukotriene receptor 2; Cysteinyl LeukotrieneR2; G protein-coupled receptor; G-protein coupled receptor GPCR21; G-protein coupled receptor HG57; HG57; hGPCR21; HPN321; KPG_011
Mass (kDA):
39.635 kDA
Human | |
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Location: | 13q14.2 |
Sequence: | 13; NC_000013.11 (48653929..48711226) |
Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
Cell membrane; Multi-pass membrane protein.
PMID: 10913337 by Takasaki J., et al. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor.
PMID: 10851239 by Heise C.E., et al. Characterization of the human cysteinyl leukotriene 2 receptor.