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- Table of Contents
Facts about Phosphomevalonate kinase.
Human | |
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Gene Name: | PMVK |
Uniprot: | Q15126 |
Entrez: | 10654 |
Belongs to: |
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No superfamily |
hPMK; HUMPMKI; phosphomevalonate kinase; PMKA; PMKASE; PMKEC 2.7.4.2; PMKI
Mass (kDA):
21.995 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (154924740..154942658, complement) |
Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.
Cytoplasm, cytosol.
Boster Bio's new PMVK-Marker is here for you. The Innovating Science Reward is an incredible opportunity for you to receive product credit and be recognized. Continue reading to learn more about Boster Bio, the PMVK marker and the Transfection Resagent. Here are the best uses that this PMVK marker can be used for:
Steven Boster is the inventor of a variety of products for immunohistochemistry. He has been called "he who converted science in the lavatory" because of his many inventions. He was able to develop hundreds of primary antibodies and grow the company into one China's largest catalog-based antibody companies. Today, Boster has created a proprietary ELISA platform called PicoKine(tm) that delivers high-sensitivity ELISA kits for IHC and cytology.
Boster Bio: Transfection Resagent, 5ug ORF cDNA clone and BHK Cells were used to successfully transfer SFV3LacZ into BHK cell lines. BHK cells were stained with Xgal to confirm the virus's infectivity. The virus was still infectious even after cell line establishment. IL-2 was also more effective than the corresponding IL-2 in BHK cells.
RNA-mediated transmission has many advantages over other methods. Although RNA-guided methods are more effective at transferring DNA into live cells than traditional methods, they require expert knowledge of viral replication. Boster bio: Transfection Resagent, 5ug ORF CDNA plasmid, as well as a BSA-free human Simian immunodeficiencyvirus, are used to efficiently transfect cells.
The tRNAval promoter element drives ribozyme gene expression and is designed to block the expression of pre-existing viral DNA. To perform gene therapy, we also use the BosterBio: Transfection Reagent as well as the 5ug ORF-cDNA plasmid. Transfection of tRNAval, which is a transfection of ribozyme DNA into B7-positive cells, is effective in blocking expression of pre-existing viral genome.
The tRNA mRNA vector-producer cells are capable of producing cDNA for mice. The protocol for transfection is shown in Table 1-1. This protocol applies to phases A-D. The highest reproducibility of all study phases is attained by vector-producer cell based on tRNA. Patients will then be fully recovered for 48 hours.
This recombinant can be used in mice with hematologic and oncology departments. It has been used in the transplantation of peripheral blood cells for patients suffering from multiple myeloma, metastatic cancer, and chronic myelogenous lesions. The promising results of inserting interleukin-2 and gene for tumor neogenesis factor into cancer cells have been demonstrated. The recombinant cDNA clone also works in patients with melanoma and is FDA approved.
After the vector-producing cells have been infused into the tumor, a positive response will be determined. The residual production cells will be disposed of in an autoclaved container. To prevent complications, there is a possibility that high dose dexamethasone might be changed. If you have had treatment for any conditions listed above, consult your doctor immediately.
The Boster Bio: Transfection Reagent is a highly efficient and efficient way to transform a cell into a therapeutic gene. This product is compatible for use with a wide range of cell lines, including human. It is also useful in many research studies. Its unique design makes the device a versatile choice for cloning, transducing, and manipulating tumor cells.
In addition to this, the Boster Transfection Reagent helps with the creation of a PCR-based cloning method. It has been clinically proven to be highly effective in producing healthy cells. Boster Transfection Reagent is also rich in useful nutrients. These nutrients can be used in any other research. If you're using this product to transduce cancer cells, you should read all the instructions carefully.
The PMVK gene is a key regulator of phosphatidylcholinesterase (PCE) activity. This protein is highly expressed by the liver. In addition to its role in the regulation of PCE activity, the anti-Phosphomevalonate kinase marker can be used for research in the field of cell cycle. It is produced from human phosphodiesterase II.
This protein is found in many tissues, including breast carcinoma cells. It is essential for MCF-7-cell viability and has been shown to be associated with breast carcinoma development. IKBKE expression can also be suppressed by targeting GFP shRNAs or shRNAs that target IKBKE. In contrast, kinase genes at Iq32 are suppressed in breast cancer cells.
This protein is best used for studies that target Foxo genes. In vivo delivery of the anti-Phosphomevalonate kinase PMVK marker involves a DNA construct with the antisense PMVK marker encoding sequence. The antisense RNA molecules can also be delivered directly into the tissue. The antisense molecules could be delivered in a systematic manner using modified RNAi Vectors.
The Anti-Phosphomevalonate PMVK protein is located predominantly in the nucleus of cells and can be detected by antibody staining. It is important for you to know that the protein is subcellular within the tracheal & salivary glands. It can also detected in the skeletal muscle and lungs.
The best uses of the Anti-PhosphomeValonate kinase PMVVK gene markers are described below. Refer to a reference book for a comprehensive overview of all the PMVK gene marker markers. The PMVK gene could be used as a cancer diagnostic marker. It is also used in anti-neoplastic therapeutics.
The Anti-Phosphomevalonate PMVK gene is highly expressed in many cancer tissues. It is unique in its structure, making it useful in many clinical trials. It is not known how it functions in research on cancer. It is vital to understand how this protein functions in the human body. When the protein is expressed in the liver, it can be detected by immunohistochemistry.
PMID: 8663599 by Chambliss K.L., et al. Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.
PMID: 10191291 by Olivier L.M., et al. Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.