PLK4 Antibodies

AND PLK4 ELISA kits, PLK4 Proteins

Many biological assays use antibodies to detect PLK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLK4 antibodies...

We validate the specificity of these antibodies to PLK4 by testing them on tissues known to express PLK4 positively and negatively. Browse below to find the PLK4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLK4 Infographic by Boster Bio

All PLK4 Products

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Product

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Specificity

Applications

Price

Anti-PLK4 Antibody

Human, Mouse, Rat

$405
Cat # A01947
100ul

Anti-PLK4 Mouse Monoclonal Antibody [Clone ID: OTI3G10]

Human

$523
Cat # M01947
100 µl

PLK4 (NM_014264) Human Over-expression Lysate

Human

$628
Cat # LS010733
100 µg

PLK4 Overview

Facts about Serine/threonine-protein kinase PLK4.

PLK4 3D structure. Source: alphafold

Serine/threonine-protein kinase PLK4 (PLK4)

Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification during the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.

Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication indicates a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.

Gene Information

Human
Gene Name:	PLK4
Uniprot:	O00444
Entrez:	10733

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11.21; PLK-4; polo-like kinase 4 (Drosophila); polo-like kinase 4SAKSTK18serine/threonine kinase 18; Sak; serine/threonine protein kinase SAK; Serine/threonine-protein kinase 18; serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase Sak; Snk akin kinase

Molecular Weight

Mass (kDA):
108.972 kDA

Genomic Context


Human

Location:	4q28.1
Sequence:	4; NC_000004.12 (127880893..127899224)

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.