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Cohesin subunit SA-3 Antibodies
AND STAG3 ELISA kits, Cohesin subunit SA-3 Proteins
Many biological assays use antibodies to detect Cohesin subunit SA-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cohesin subunit SA-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cohesin subunit SA-3 antibodies...
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STAG3 Overview
Facts about Cohesin subunit SA-3.
Cohesin subunit SA-3 (STAG3)
Meiosis specific part of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication.
The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Gene Information
| Human | |
|---|---|
| Gene Name: | STAG3 |
| Uniprot: | Q9UJ98 |
| Entrez: | 10734 |
Family
| Belongs to: |
|---|
| SCC3 family |
Alternative Names
cohesin subunit SA-3; SCC3 homolog 3; stromal antigen 3stromalin 3; stromalin-3
Molecular Weight
Mass (kDA):
139.034 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (100177563..100219334) |
Tissue Specificity
Testis specific.
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere. Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation.
Diseases
- Infertility
- Male Infertility
- Sterility
- Malignant Neoplasms
- Cholangiocarcinoma
- Instabilities, Chromosomal
- Congenital Abnormality
- Williams Syndrome
- Allelic Imbalance
- Polyploidy
- Aneuploidy
- Neoplasms, Glandular And Epithelial
Pathways
- Meiosis
- Prophase
- Anaphase
- Sister Chromatid Cohesion
- Metaphase
- Pachytene
- Mitosis
- Chromosome Segregation
- Meiotic Prophase I
- Diplotene
- Localization
- Spermatogenesis
- Meiosis I
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STAG3
bosterbio.com/bosterbio-gene-info-cards/STAG3
References
PMID: 10698974 by Pezzi N., et al. STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams- Beuren syndrome deletion.
PMID: 12034751 by Prieto I., et al. STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.