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PLEKHG5 Antibodies
AND PLEKHG5 ELISA kits, PLEKHG5 Proteins
Many biological assays use antibodies to detect PLEKHG5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLEKHG5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLEKHG5 antibodies...
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PLEKHG5 Infographic by Boster Bio
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PLEKHG5 Overview
Facts about Pleckstrin homology domain-containing family G member 5.
Pleckstrin homology domain-containing family G member 5 (PLEKHG5)
Guanine nucleotide exchange factor that activates RHOA and possibly the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation.
Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PLEKHG5 |
| Uniprot: | O94827 |
| Entrez: | 57449 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CMTRIC; DSMA4; GEF720; KIAA0720Guanine nucleotide exchange factor 720; NFkB activating protein; novel PH domain-containing protein; PH domain-containing family G member 5; pleckstrin homology domain containing family G member 5; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; pleckstrin homology domain-containing family G member 5; Syx; Tech
Molecular Weight
Mass (kDA):
117.451 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.31 |
| Sequence: | 1; NC_000001.11 (6466092..6520061, complement) |
Tissue Specificity
Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.
Subcellular Localizations
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Cell junction. Cell projection, lamellipodium. Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane. Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells.
Diseases
- Neuroblastoma
- Motor Neuron Disease
- Cell Transformation, Neoplastic
- Charcot-marie-tooth Disease
- Muscular Atrophy
- Neurotoxicity Syndromes
- Atrophy
Pathways
- Transport
- Cell Cycle
- Cell Differentiation
- Rna Processing
- Pathogenesis
PTMs
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHG5
bosterbio.com/bosterbio-gene-info-cards/PLEKHG5
References
PMID: 12761501 by Matsuda A., et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
PMID: 11704860 by De Toledo M., et al. The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.