Pld6 Antibodies

AND Pld6 ELISA kits, Pld6 Proteins

Many biological assays use antibodies to detect Pld6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pld6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pld6 antibodies...

We validate the specificity of these antibodies to Pld6 by testing them on tissues known to express Pld6 positively and negatively. Browse below to find the Pld6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: Jmjd4

Pld6 Infographic by Boster Bio

All Pld6 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PLD6 Antibody (Center)

Human, Mouse

$298
Cat # A10904
80 µl

Anti-PLD6 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A10904-1
100 µg/vial

Pld6 Overview

Facts about Mitochondrial cardiolipin hydrolase.

Mitochondrial cardiolipin hydrolase (Pld6)

Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. PiRNAs provide essential protection against the activity of mobile genetic elements.

PiRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (PubMed:23064227, PubMed:23064230). Has been proposed to serve as a cardiolipin hydrolase to create phosphatidic acid in mitochondrial surface (PubMed:21397847, PubMed:21397848).

Gene Information

Mouse
Gene Name:	Pld6
Uniprot:	Q5SWZ9
Entrez:	194908

Family

Belongs to:

phospholipase D family

Alternative Names

Choline phosphatase 6; EC 3.1.4.-; Mitochondrial phospholipase; MitoPLD; Phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family, member 6; Phospholipase D6; PLD 6; Protein zucchini homolog

Molecular Weight

Mass (kDA):
25.041 kDA

Genomic Context


Mouse

Location:	11\|11 B1.3
Sequence:	11;

Tissue Specificity

Predominantly expressed in testis (at protein level). Also expressed at high levels in growing ovary.

Diseases

Down Syndrome
Trisomy

Pathways

Methylation
Dna Methylation

PTMs

Demethylation

Methylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pld6

References

PMID: 21397847 by Watanabe T., et al. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.

PMID: 21397848 by Huang H., et al. piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.