PLCE1 Antibodies

AND PLCE1 ELISA kits, PLCE1 Proteins

Many biological assays use antibodies to detect PLCE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLCE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLCE1 antibodies...

We validate the specificity of these antibodies to PLCE1 by testing them on tissues known to express PLCE1 positively and negatively. Browse below to find the PLCE1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLCE1 Infographic by Boster Bio

All PLCE1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PLCE1 Antibody

Human

IHC

$380
Cat # A02360
100ul

Phospholipase C epsilon 1 (PLCE1) (NM_016341) Human Over-expression Lysate

Human

$960
Cat # LS051196
100 µg

Anti-PLCE1 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A02360-1
100 µg/vial

PLCE1 Overview

Facts about 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1.

PLCE1 3D structure. Source: alphafold

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)

The creation of this second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme that also modulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity.

As an effector of both heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. .

Gene Information

Human
Gene Name:	PLCE1
Uniprot:	Q9P212
Entrez:	51196

Family

Belongs to:

No superfamily

Alternative Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Molecular Weight

Mass (kDA):
258.715 kDA

Genomic Context


Human

Location:	10q23.33
Sequence:	10; NC_000010.11 (93993931..94332823)

Tissue Specificity

Widely expressed. Isoform 1 is broadly expressed and only absent in peripheral blood leukocytes. Isoform 2 is specifically expressed in placenta, lung and spleen.

Subcellular Localizations

Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLCE1

References

PMID: 11022048 by Song C., et al. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.

PMID: 11022047 by Lopez I., et al. A novel bifunctional phospholipase C that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway.