Plakophilin-4 Antibodies

AND PKP4 ELISA kits, Plakophilin-4 Proteins

Many biological assays use antibodies to detect Plakophilin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Plakophilin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Plakophilin-4 antibodies...

We validate the specificity of these antibodies to Plakophilin-4 by testing them on tissues known to express PKP4 positively and negatively. Browse below to find the PKP4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PKP4 Infographic by Boster Bio

All PKP4 Products

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Specificity

Applications

Price

Anti-Plakophilin 4 PKP4 Antibody

5 Q&As

Human, Mouse

$399
Cat # A05639
100μl

Anti-Plakophilin 4 PKP4 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A05639-1
100ul

Plakophilin 4 (PKP4) (NM_003628) Human Over-expression Lysate

Human

$960
Cat # LS008502
100 µg

PKP4 Overview

Facts about Plakophilin-4.

PKP4 3D structure. Source: alphafold

Plakophilin-4 (PKP4)

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.

Gene Information

Human
Gene Name:	PKP4
Uniprot:	Q99569
Entrez:	8502

Family

Belongs to:

beta-catenin family

Alternative Names

catenin 4; FLJ42243; p0071FLJ31261; plakophilin 4; plakophilin-4

Molecular Weight

Mass (kDA):
131.868 kDA

Genomic Context


Human

Location:	2q24.1
Sequence:	2; NC_000002.12 (158456952..158681429)

Subcellular Localizations

Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.

Diseases

Dental Plaque
Tissue Adhesions
Alzheimer's Disease
Carcinoma
Neoplasms
Malignant Squamous Cell Neoplasm
Cell Transformation, Neoplastic
Oropharyngeal Disorders
Neoplasm Metastasis
Cardiac Arrhythmia
Neuromuscular Diseases
Kidney Neoplasm

Brazilian Pemphigus Foliaceus
Carcinogenesis
Oropharyngeal Neoplasms
Arrhythmogenic Right Ventricular Dysplasia
Malignant Neoplasm Of Oropharynx
Renal Cell Carcinoma

Interacting Proteins

ATPAF2
DLG1
ERBIN
GOLGA2
LZTS2

SCRIB
TRIM23

Pathways

Localization
Cell Adhesion
Cytokinesis
Adherens Junction Assembly
Cell Junction Assembly
Cell Migration
Regulation Of Cell Adhesion
Desmosome Assembly
Induction Of Apoptosis
Establishment Of Cell Polarity
Brain Development
Immune Response

Vasculogenesis
Rna Localization
Regeneration
Cell Division
Cell Growth
Cell-cell Adhesion

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKP4

References

PMID: 8937994 by Hatzfeld M., et al. Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins.

PMID: 17115030 by Wolf A., et al. The armadillo protein p0071 regulates Rho signalling during cytokinesis.