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- Table of Contents
Facts about Piwi-like protein 3.
Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are made by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).
Human | |
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Gene Name: | PIWIL3 |
Uniprot: | Q7Z3Z3 |
Entrez: | 440822 |
Belongs to: |
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argonaute family |
HIWI3; piwi-like 3 (Drosophila); piwi-like protein 3
Mass (kDA):
101.089 kDA
Human | |
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Location: | 22q11.23 |
Sequence: | 22; NC_000022.11 (24719034..24774720, complement) |
Expressed in testis.
Cytoplasm. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
PMID: 12906857 by Sasaki T., et al. Identification of eight members of the Argonaute family in the human genome.