PINX1 Antibodies

AND PINX1 ELISA kits, PINX1 Proteins

Many biological assays use antibodies to detect PINX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PINX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PINX1 antibodies...

We validate the specificity of these antibodies to PINX1 by testing them on tissues known to express PINX1 positively and negatively. Browse below to find the PINX1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PINX1 Infographic by Boster Bio

All PINX1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PINX1 Antibody Picoband®

1 Q&As

Human

$370
Cat # PB9498
100 μg/vial

Anti-PINX1 Antibody

Human, Mouse, Rat

$405
Cat # A03576
100ul

Anti-PinX1 Antibody

Human

ELISA, IHC

$380
Cat # A03576-1
100ul

PINX1 (NM_017884) Human Recombinant Protein

$813
Cat # PROTQ96BK5
20 µg

PINX1 (NM_017884) Human Over-expression Lysate

Human

$628
Cat # LS054984
100 µg

PINX1 Overview

Facts about PIN2/TERF1-interacting telomerase inhibitor 1.

PINX1 3D structure. Source: alphafold

PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1)

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres.

Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.

Gene Information

Human
Gene Name:	PINX1
Uniprot:	Q96BK5
Entrez:	54984

Family

Belongs to:

PINX1 family

Alternative Names

FLJ20565; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTLPinX1; LPTS67-11-3 protein; MGC8850; PIN2 interacting protein 1; PIN2/TERF1 interacting, telomerase inhibitor 1; PIN2/TERF1-interacting telomerase inhibitor 1; PIN2-interacting protein 1; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1

Molecular Weight

Mass (kDA):
37.035 kDA

Genomic Context


Human

Location:	8p23.1
Sequence:	8; NC_000008.11 (10764961..10839899, complement)

Tissue Specificity

Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Telomere Shortening
Liver Carcinoma
Stomach Neoplasms
Cell Transformation, Neoplastic
Liver Neoplasms
Malignant Neoplasm Of Stomach
Mammary Neoplasms
Leukemia
Neoplasm Metastasis

Malignant Neoplasm Of Breast
Instabilities, Chromosomal
Metastatic Malignant Neoplasm To The Lymph Node
Neoplasms, Experimental
Hepatitis B
Immunologic Deficiency Syndromes

Interacting Proteins

TERF1

Pathways

Localization
Telomere Maintenance
Mitosis
Cell Growth
Cell Proliferation
Senescence
Cell Cycle
S Phase
Rna Interference
Cellular Senescence
Aging
Chromosome Segregation
Anaphase

Interphase
Oncogenesis
Regulation Of Telomerase Activity
Methylation
Cell Death
Rna Processing
Cell Migration

PTMs

Phosphorylation
Acetylation

Methylation
Ubiquitination

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PINX1

References

PMID: 11003615 by Liao C., et al. Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma.

PMID: 11701125 by Zhou X.Z., et al. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.