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Facts about Serine/threonine-protein kinase pim-3.
Additionally to this function on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth (By similarity).
Rat | |
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Gene Name: | Pim3 |
Uniprot: | O70444 |
Entrez: | 64534 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11.1; pim-3 oncogene; pim-3; serine/threonine kinase Pim-3; serine/threonine-protein kinase pim-3
Mass (kDA):
36.002 kDA
Rat | |
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Location: | 7q34 |
Sequence: | 7; |
Detected in various tissues, including brain.
PMID: 9632723 by Feldman J.D., et al. KID-1, a protein kinase induced by depolarization in brain.