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PIM2 Antibodies
AND PIM2 ELISA kits, PIM2 Proteins
Many biological assays use antibodies to detect PIM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIM2 antibodies...
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PIM2 Infographic by Boster Bio
All PIM2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, WB
$523
Cat # M03053
100 µl
Cat # M03053
100 µl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, WB
$523
Cat # M03053-1
100 µl
Cat # M03053-1
100 µl
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # M03053-2
100 μl/vial
Cat # M03053-2
100 μl/vial
PIM2 Overview
Facts about Serine/threonine-protein kinase pim-2.
Serine/threonine-protein kinase pim-2 (PIM2)
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD.
Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIM2 |
| Uniprot: | Q9P1W9 |
| Entrez: | 11040 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; pim-2 oncogene; PIM2; pim-2h; proto-oncogene Pim-2 (serine threonine kinase); serine/threonine protein kinase pim-2; serine/threonine-protein kinase pim-2
Molecular Weight
Mass (kDA):
34.19 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.23 |
| Sequence: | X; NC_000023.11 (48913182..48919024, complement) |
Tissue Specificity
Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.
Diseases
- Neoplasms
- Lymphoma
- Malignant Neoplasms
- Leukemia
- Cell Transformation, Neoplastic
- Leukemogenesis
- Malignant Paraganglionic Neoplasm
- Tuberculosis
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Diffuse Large B-cell Lymphoma
- Myeloid Leukemia
- B-cell Lymphomas
Interacting Proteins
- ZNF821
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Death
- Pathogenesis
- Translation
- Cell Growth
- Cell Cycle Arrest
- Immune Response
- Cell Differentiation
- G1 Phase
- Glycosylation
- Dna Repair
- Angiogenesis
PTMs
- Phosphorylation
- Glycosylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIM2
bosterbio.com/bosterbio-gene-info-cards/PIM2
References
PMID: 9804974 by Baytel D., et al. The human Pim-2 proto-oncogene and its testicular expression.
PMID: 16548883 by Leong W.F., et al. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.