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B4GAT1 Antibodies
AND B4GAT1 ELISA kits, B4GAT1 Proteins
Many biological assays use antibodies to detect B4GAT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with B4GAT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop B4GAT1 antibodies...
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B4GAT1 Overview
Facts about Beta-1,4-glucuronyltransferase 1.
Beta-1,4-glucuronyltransferase 1 (B4GAT1)
Beta-1,4-glucuronyltransferase involved in O- mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue on a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which can be further elongated by LARGE1, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699, PubMed:25279697).
Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; through its role in O-mannosylation of alpha- dystroglycan (DAG1) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | B4GAT1 |
| Uniprot: | O43505 |
| Entrez: | 11041 |
Family
| Belongs to: |
|---|
| glycosyltransferase 49 family |
Alternative Names
B3GNT1; B3GN-T1; B4GAT1; beta-1,3-N-acetylglucosaminyltransferase bGnT-6; BETA3GNTI; EC 2.4.1.149; i-beta-1,3-N-acetylglucosaminyltransferase; iGAT; iGNT; MDDGA13; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1B3GNT6; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
Molecular Weight
Mass (kDA):
47.119 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.2 |
| Sequence: | 11; NC_000011.10 (66345374..66347629, complement) |
Tissue Specificity
In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver.
Subcellular Localizations
Golgi apparatus membrane; Single-pass type II membrane protein. Localizes near the trans-Golgi apparatus.
Diseases
- Neoplasm Metastasis
- Malignant Neoplasm Of Prostate
- Classical Galactosemia
- Tumor Progression
- Renal Fibrosarcoma
- Gastritis
- Fibrosarcoma
- Malignant Neoplasms
- Udpglucose 4-epimerase Deficiency Disease
Interacting Proteins
- LARGE2
Pathways
- Glycosylation
- Transport
- Localization
- Cell Migration
- Oxidative Phosphorylation
- Spermatogenesis
- Protein Glycosylation
- Dna Replication
- System Development
- Axon Guidance
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/B4GAT1
bosterbio.com/bosterbio-gene-info-cards/B4GAT1
References
PMID: 9405606 by Sasaki K., et al. Expression cloning of cDNA encoding a human beta-1,3-N- acetylglucosaminyltransferase that is essential for poly-N- acetyllactosamine synthesis.
PMID: 19587235 by Bao X., et al. Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase.