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Pik3r6 Antibodies
AND Pik3r6 ELISA kits, Pik3r6 Proteins
Many biological assays use antibodies to detect Pik3r6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pik3r6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pik3r6 antibodies...
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Pik3r6 Overview
Facts about Phosphoinositide 3-kinase regulatory subunit 6.
Phosphoinositide 3-kinase regulatory subunit 6 (Pik3r6)
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to induce activation of PIK3CG by beta-gamma G protein dimers.
The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins compared to PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling appears to involve RRAS.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pik3r6 |
| Uniprot: | Q3U6Q4 |
| Entrez: | 104709 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C17orf38; chromosome 17 open reading frame 38; FLJ34500; HsT41028; p84; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein; p87 PI3K adapter protein; p87(PIKAP); p87PIKAPDKFZp666P158; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; phosphoinositide 3-kinase regulatory subunit 6; phosphoinositide-3-kinase, regulatory subunit 6; PI3Kgamma adapter protein of 87 kDa
Molecular Weight
Mass (kDA):
84.663 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 11|11 B3 |
| Sequence: | 11; |
Research Areas
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pik3r6
bosterbio.com/bosterbio-gene-info-cards/Pik3r6
References
PMID: 16476736 by Voigt P., et al. Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
PMID: 15797027 by Suire S., et al. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma.