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PIK3R4 Antibodies
AND PIK3R4 ELISA kits, PIK3R4 Proteins
Many biological assays use antibodies to detect PIK3R4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIK3R4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIK3R4 antibodies...
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PIK3R4 Infographic by Boster Bio
All PIK3R4 Products
Product
Figures
Specificity
Applications
Price
$1249
Cat # PROTQ99570
20 µg
Cat # PROTQ99570
20 µg
Human, Mouse, Rat
IHC
$523
Cat # M06618
100 µl
Cat # M06618
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M06618-1
100 μl/vial
Cat # M06618-1
100 μl/vial
Human
$628
Cat # LS030849
100 µg
Cat # LS030849
100 µg
PIK3R4 Overview
Facts about Phosphoinositide 3-kinase regulatory subunit 4.
Phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4)
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in several membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
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Gene Information
| Human | |
|---|---|
| Gene Name: | PIK3R4 |
| Uniprot: | Q99570 |
| Entrez: | 30849 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; MGC102700; p150; phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PIK3R4; VPS 15; VPS15
Molecular Weight
Mass (kDA):
153.103 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q22.1 |
| Sequence: | 3; NC_000003.12 (130678934..130746829, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor. As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Adenocarcinoma
- Malignant Squamous Cell Neoplasm
- Metastatic Melanoma
- Escherichia Coli Infections
- Melanoma
- Hypopigmentation Disorder
- Uterine Cervical Neoplasm
- Neurofibromatosis 1
- Bleeding Tendency
- Premature Aging Syndrome
Interacting Proteins
- NRBF2
Pathways
- Autophagy
- Cell Division
- Drug Resistance
- Macroautophagy
- Phagocytosis
- Aging
- Regulation Of Autophagy
PTMs
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3R4
bosterbio.com/bosterbio-gene-info-cards/PIK3R4
References
PMID: 8999962 by Panaretou C., et al. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.PtdIns 3-kinase complex.
PMID: 14617358 by Stein M.P., et al. Human VPS34 and p150 are Rab7 interacting partners.