PIK3R2 Antibodies

Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2)

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, such as AKT1 and PDPK1, triggering signaling cascades involved in cell growth, survival, proliferation, motility and morphology.

Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).

Gene Information

Human
Gene Name:	PIK3R2
Uniprot:	O00459
Entrez:	5296

Family

Belongs to:
PI3K p85 subunit family

Alternative Names

P85B; p85-beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta); PI 3Kinase p85 beta; PI 3-Kinase p85 beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PIK3R2; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinas

Molecular Weight

Mass (kDA):
81.545 kDA

Genomic Context

Human
Location:	19p13.11
Sequence:	19; NC_000019.10 (18153163..18170532)

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Breast
• Carcinoma
• Mammary Neoplasms
• Mutation Abnormality
• Tumor Angiogenesis
• Ovarian Neoplasm
• Impaired Glucose Tolerance
• Tumor Progression
• Endometrial Neoplasms
• Endometrial Polyp

• Carcinogenesis
• Insulin Resistance
• Malignant Neoplasm Of Ovary
• Brain Neoplasms
• Obesity
• Leukemia
• Endometrial Carcinoma

Interacting Proteins

• AR
• CBL
• DYDC1
• EGFR
• ERBB2

• ERBB3
• GAB1
• GOLGA2
• GRB2
• HTT

• IKZF3
• KIT
• KRT15
• KRT20
• KRT38

• MET
• MRFAP1L1
• PIK3CB
• RINT1
• TRIM23

Pathways

• Secretion
• Angiogenesis
• Pathogenesis
• Insulin Receptor Signaling Pathway
• Insulin Secretion
• Brain Development
• Vasculogenesis
• Inflammatory Response
• Cell Division

• Chemokine Secretion
• Cell Cycle
• Exocytosis
• Regulation Of Insulin Secretion

PTMs

• Phosphorylation

• Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3R2

Best Uses Of The PIK3R2 Marker

You may be considering buying the Boster Bio. If so, you might be wondering how to optimize your experiment. We'll show you how to improve your Boster Bio experiments and give you troubleshooting advice to make your experiments run more smoothly. Here are some of our favorite Boster Bio tips. If you're not able to find what you require, we suggest using our Boster Bio troubleshooting guide.

Boster Bio: the PIK3R2 marker

PIK3R2 is an important protein that has numerous uses both in the cell and within the body. It plays an important role in the immune system and regulates numerous biochemical processes. This protein is utilized by scientists to identify cancer cells and other diseases. Researchers who study this protein, are known as "pik3rases". PIK3Rases is a group of proteins that are found in human cells as well as in other tissues. They control cell death through signaling pathways.

Boster Bio optimization

The Boster Microplate reader is an excellent tool to measure absorbance at around 450nm. It can be utilized with 0.5 milliliters of aqueous solutions. Multichannel pipettes work best for large samples. To make data sharing easier the company offers product credits. Boster Bio also offers several optimization guides to help you get the most of your results.

Boster Bio troubleshooting

Boster Bio Anti-Phospho-PI 3-kinase p8 Beta (Y464) antibody is a great option for experiments with PIK3R2. This antibody reacts with human and mouse cells. It targets the P8 beta phosphorylation site. Boster Bio also offers product credit which can be used to purchase additional antibody Reagents.