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- Table of Contents
Facts about Phosphatidylinositol 4-kinase beta.
Involved in Golgi-to-plasma membrane trafficking (By similarity). .
Human | |
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Gene Name: | PI4KB |
Uniprot: | Q9UBF8 |
Entrez: | 5298 |
Belongs to: |
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PI3/PI4-kinase family |
DKFZp686O1820; EC 2.7.1; EC 2.7.1.67; FLJ30129; phosphatidylinositol 4-kinase, catalytic, beta; pi4K92; PI4Kbeta; PI4K-beta; PI4KIIIBETA; type III phosphatidylinositol 4-kinase beta; wortmannin-sensitive
Mass (kDA):
91.379 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (151291797..151327715, complement) |
Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Cytoplasm, perinuclear region. Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the
PMID: 9405935 by Suzuki K., et al. Identification and characterization of a novel human phosphatidylinositol 4-kinase.
PMID: 9405938 by Saito T., et al. Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene.