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- Table of Contents
Facts about Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform.
Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling.
Human | |
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Gene Name: | PIK3CD |
Uniprot: | O00329 |
Entrez: | 5293 |
Belongs to: |
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PI3/PI4-kinase family |
EC 2.7.1; EC 2.7.1.153; p110D; P110DELTA; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide; PI 3Kinase p110 delta; PI 3-Kinase p110 delta; PI3K; PI3K-delta; PI3-kinase p110 subunit delta; PI3-kinase subunit delta; PIK3CD; PtdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta
Mass (kDA):
119.479 kDA
Human | |
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Location: | 1p36.22 |
Sequence: | 1; NC_000001.11 (9629889..9729114) |
Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes.
Cytoplasm.
PMID: 9113989 by Vanhaesebroeck B.A.M., et al. P110delta, a novel phosphoinositide 3-kinase in leukocytes.
PMID: 9235916 by Chantry D., et al. p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
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