Histone lysine demethylase PHF8 (PHF8)

Histone lysine demethylase with selectivity for the di- and monomethyl conditions that plays an integral role cell cycle progression, rDNA transcription and brain growth. Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks.

Involved in cell cycle progression by being required to restrain G1-S transition. Acts as a coactivator of rDNA transcription, by triggering polymerase I (pol I) mediated transcription of rRNA genes.