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- Table of Contents
Facts about Histone lysine demethylase PHF8.
Involved in cell cycle progression by being required to restrain G1-S transition. Acts as a coactivator of rDNA transcription, by triggering polymerase I (pol I) mediated transcription of rRNA genes.
Human | |
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Gene Name: | PHF8 |
Uniprot: | Q9UPP1 |
Entrez: | 23133 |
Belongs to: |
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JHDM1 histone demethylase family |
EC 1.14.11.27; histone lysine demethylase PHF8; jumonji C domain-containing histone demethylase 1F; KIAA1111ZNF422JHDM1F; MRXSSD; PHD finger protein 8DKFZp686E0868
Mass (kDA):
117.864 kDA
Human | |
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Location: | Xp11.22 |
Sequence: | X; NC_000023.11 (53936680..54048935, complement) |
Nucleus. Nucleus, nucleolus. Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis.
PMID: 16199551 by Laumonnier F., et al. Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate.
PMID: 20531378 by Zhu Z., et al. PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.