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- Table of Contents
Facts about Lysine-specific demethylase PHF2.
Demethylation of ARID5B contributes to goal the PHF2-ARID5B complicated to target promoters, where PHF2 mediates demethylation of dimethylated'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver.
Human | |
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Gene Name: | PHF2 |
Uniprot: | O75151 |
Entrez: | 5253 |
Belongs to: |
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JHDM1 histone demethylase family |
GRC5; jumonji C domain-containing histone demethylase 1E; KIAA0662JHDM1E; MGC176680; PHD finger protein 2
Mass (kDA):
120.775 kDA
Human | |
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Location: | 9q22.31 |
Sequence: | 9; NC_000009.12 (93576584..93679587) |
Widely expressed, including in liver (at protein level).
Nucleus, nucleolus. Chromosome, centromere, kinetochore.
PMID: 10051327 by Hasenpusch-Theil K., et al. PHF2, a novel PHD finger gene located on human chromosome 9q22.
PMID: 20813266 by Ohta S., et al. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.