PHKA1 Antibodies

AND PHKA1 ELISA kits, PHKA1 Proteins

Many biological assays use antibodies to detect PHKA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHKA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHKA1 antibodies...

We validate the specificity of these antibodies to PHKA1 by testing them on tissues known to express PHKA1 positively and negatively. Browse below to find the PHKA1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHKA1 Infographic by Boster Bio

All PHKA1 Products

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Product

Figures

Specificity

Applications

Price

Anti-KPB1/2 PHKA1 Antibody

3 Q&As

Human, Mouse, Rat

IF, WB

$360
Cat # A10086
100 µl

PHKA1 (NM_002637) Human Recombinant Protein

$1062
Cat # PROTP46020
20 µg

PHKA1 (NM_002637) Human Over-expression Lysate

Human

$960
Cat # LS005255
100 µg

PHKA1 Overview

Facts about Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform.

PHKA1 3D structure. Source: alphafold

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (PHKA1)

Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

Gene Information

Human
Gene Name:	PHKA1
Uniprot:	P46020
Entrez:	5255

Family

Belongs to:

phosphorylase b kinase regulatory chain family

Alternative Names

MGC132604; PHKA; phosphorylase b kinase regulatory subunit alpha skeletal muscle isoform; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase kinase alpha M subunit; phosphorylase kinase, alpha 1 (muscle); phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis

Molecular Weight

Mass (kDA):
137.312 kDA

Genomic Context


Human

Location:	Xq13.1
Sequence:	X; NC_000023.11 (72578814..72714306, complement)

Tissue Specificity

Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested.

Subcellular Localizations

Cell membrane; Lipid-anchor; Cytoplasmic side.

Diseases

Glycogen Storage Disease
Myopathy
Glycogen Storage Disease Type V
Isodicentric Chromosome
Pain
Sex Chromosome Aberrations
Storage Disease
Muscle Weakness
Glycogen Storage Disease Type Viii
Stomach Neoplasms
Neoplasm Metastasis

Metastatic Malignant Neoplasm To The Lymph Node
Aplasia Of Muscle
De Novo Mutation
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Neoplasms

Pathways

Metaphase
Pathogenesis
Dosage Compensation
Localization

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHKA1

References

PMID: 8226841 by Wuellrich A., et al. The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution.

PMID: 12825073 by Burwinkel B., et al. Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases.