PHD finger protein 10 Antibodies

AND PHF10 ELISA kits, PHD finger protein 10 Proteins

Many biological assays use antibodies to detect PHD finger protein 10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHD finger protein 10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHD finger protein 10 antibodies...

We validate the specificity of these antibodies to PHD finger protein 10 by testing them on tissues known to express PHF10 positively and negatively. Browse below to find the PHF10 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHF10 Infographic by Boster Bio

All PHF10 Products

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PHF10 (NM_018288) Human Over-expression Lysate

Human

$628
Cat # LS055274
100 µg

Anti-PHF10 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A08195-1
100 µg/vial

PHF10 Overview

Facts about PHD finger protein 10.

PHF10 3D structure. Source: alphafold

PHD finger protein 10 (PHF10)

Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complicated ) and is necessary for the proliferation of neural progenitors. During neural development a change from a stem/progenitor into a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become dedicated to their adult condition.

The transition from proliferating neural stem/progenitor cells into post-mitotic neurons requires a change in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF).

Gene Information

Human
Gene Name:	PHF10
Uniprot:	Q8WUB8
Entrez:	55274

Family

Belongs to:

SAYP family

Alternative Names

BAF45a; BAF45APHD zinc finger protein XAP135; BRG1-associated factor 45a; FLJ10975; MGC111009; PHD finger protein 10; XAP135BRG1-associated factor, 45-KD, A

Molecular Weight

Mass (kDA):
56.051 kDA

Genomic Context


Human

Location:	6q27
Sequence:	6; NC_000006.12 (169703902..169724500, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Stomach Neoplasms
Malignant Neoplasm Of Stomach
Neoplasms
Leishmaniasis, Visceral
Diabetes Mellitus
Leishmaniasis
Diabetes Mellitus, Insulin-dependent
Dysequilibrium Syndrome
Cell Transformation, Neoplastic
Congenital Abnormality
Chromosome Break
Synovial Sarcoma

Spina Bifida
Autoimmune Diseases
Sarcoma
Carcinogenesis
Paired Helical Filament
Autoimmune Reaction
Colorectal Neoplasms

Interacting Proteins

L3MBTL2

Pathways

Cell Proliferation
Cell Cycle
Cell Growth
Pathogenesis
Oogenesis
Senescence
Replicative Senescence
Programmed Cell Death
Cell Death

Immune Response
Dna Repair
Regulation Of Gene Expression

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHF10

References

PMID: 20068294 by Banga S.S., et al. PHF10 is required for cell proliferation in normal and SV40- immortalized human fibroblast cells.

PMID: 11827455 by Aradhya S., et al. Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28.