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PHD finger protein 1 Antibodies
AND PHF1 ELISA kits, PHD finger protein 1 Proteins
Many biological assays use antibodies to detect PHD finger protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHD finger protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHD finger protein 1 antibodies...
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PHF1 Overview
Facts about PHD finger protein 1.
PHD finger protein 1 (PHF1)
Polycomb group (PcG) that specifically binds histone H3 trimethylated in'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs).
Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however uncertain whether recruitment of the PRC2 complex to H3K36me3 contributes to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 to H3K36me3 loci (PubMed:18285464 and PubMed:23273982).
Gene Information
| Human | |
|---|---|
| Gene Name: | PHF1 |
| Uniprot: | O43189 |
| Entrez: | 5252 |
Family
| Belongs to: |
|---|
| Polycomblike family |
Alternative Names
hPCl1; MTF2L2; PCL1; PHD finger protein 1; PHF2; Polycomb-like protein 1; Protein PHF1
Molecular Weight
Mass (kDA):
62.106 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.32 |
| Sequence: | 6; NC_000006.12 (33410751..33416443) |
Tissue Specificity
Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney.
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co-localizes with NEK6 in the centrosome.
Diseases
- Alzheimer's Disease
- Neurofibrillary Tangles
- Neoplasms
- Tauopathies
- Dementia
- Neurodegenerative Disorders
- Endometrial Polyp
- Neuroblastoma
- Sarcoma
- Malignant Neoplasms
- Endometrial Stromal Sarcoma
- Dental Plaque
Interacting Proteins
- ATXN7L1
- BIRC7
- CALCOCO2
- EZH2
- HSD17B14
- NAB2
- PDLIM7
- RBPMS
- TFCP2
- THAP1
Pathways
- Hyperphosphorylation
- Methylation
- Pathogenesis
- Transport
- Gene Silencing
- Localization
- Cell Death
- Aging
- Proteolysis
- Secretory Pathway
- Protein Phosphorylation
- Programmed Cell Death
- Neurogenesis
PTMs
- Phosphorylation
- Methylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHF1
bosterbio.com/bosterbio-gene-info-cards/PHF1
References
PMID: 9545646 by Coulson M., et al. The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster.
PMID: 16397222 by Micci F., et al. Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.