PHC3 Antibodies

AND PHC3 ELISA kits, PHC3 Proteins

Many biological assays use antibodies to detect PHC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHC3 antibodies...

We validate the specificity of these antibodies to PHC3 by testing them on tissues known to express PHC3 positively and negatively. Browse below to find the PHC3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHC3 Infographic by Boster Bio

All PHC3 Products

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Specificity

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Anti-Polyhomeotic-like protein 3 PHC3 Antibody

Human, Mouse, Rat

ELISA, WB

$449
Cat # A08917
0.1 mg

Anti-PHC3 Antibody (C-Term)

Human

IHC-P, WB

$299
Cat # M08917
50 µl

PHC3 Overview

Facts about Polyhomeotic-like protein 3.

PHC3 3D structure. Source: alphafold

Polyhomeotic-like protein 3 (PHC3)

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Information

Human
Gene Name:	PHC3
Uniprot:	Q8NDX5
Entrez:	80012

Family

Belongs to:

No superfamily

Alternative Names

DKFZp313K1221; early development regulator 3; Early development regulatory protein 3; EDR3FLJ12729; FLJ12967; Homolog of polyhomeotic 3; HPH3; MGC88144; PH3; polyhomeotic homolog 3 (Drosophila); polyhomeotic like 3 (Drosophila); polyhomeotic like 3; polyhomeotic-like protein 3

Molecular Weight

Mass (kDA):
106.162 kDA

Genomic Context


Human

Location:	3q26.2
Sequence:	3; NC_000003.12 (170087580..170181752, complement)

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Malignant Neoplasm Of Larynx
Laryngeal Neoplasm
Carcinoma
Malignant Squamous Cell Neoplasm
Laryngeal Squamous Cell Carcinoma
Osteosarcoma
Cell Transformation, Neoplastic
Anemia
Anemia, Sickle Cell
Bone Neoplasms

Acute Kidney Injury
Injury To Kidney
Pain
Acute Chest Syndrome
Chimera Disorder
Shock, Hemorrhagic

Interacting Proteins

Pathways

Senescence

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHC3

References

PMID: 12384788 by Tonkin E., et al. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family.

PMID: 12167701 by Levine S.S., et al. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.