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EEF1A1 Antibodies
AND EEF1A1 ELISA kits, EEF1A1 Proteins
Many biological assays use antibodies to detect EEF1A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EEF1A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EEF1A1 antibodies...
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EEF1A1 Infographic by Boster Bio
All EEF1A1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A02141-1
100ul
Cat # A02141-1
100ul
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02141-1
100 μl/vial
Cat # M02141-1
100 μl/vial
EEF1A1 Overview
Facts about Elongation factor 1-alpha 1.
Elongation factor 1-alpha 1 (EEF1A1)
This protein promotes the GTP-dependent binding of aminoacyl-tRNA into the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is consequently involved importantly in Th1 cytokine production.
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Gene Information
| Human | |
|---|---|
| Gene Name: | EEF1A1 |
| Uniprot: | P68104 |
| Entrez: | 1915 |
Family
| Belongs to: |
|---|
| TRAFAC class translation factor GTPase superfamily |
Alternative Names
CCS3; CCS-3; cervical cancer suppressor 3; CTCL tumor antigen; EE1A1; EEF-1; EEF1A; eEF1A-1; EF1AHNGC:16303; EF1a-like protein; EF-1-alpha-1; EF-Tu; elongation factor 1 alpha subunit; elongation factor 1-alpha 1; Elongation factor Tu; Eukaryotic elongation factor 1 A-1; eukaryotic translation elongation factor 1 alpha 1; eukaryotic translation elongation factor 1 alpha 1-like 14; FLJ25721; glucocorticoid receptor AF-1 specific elongation factor; GRAF-1EF; LENG7; leukocyte receptor cluster (LRC) member 7; Leukocyte receptor cluster member 7; MGC102687; MGC131894; MGC16224; prostate tumor-induci
Molecular Weight
Mass (kDA):
50.141 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q13 |
| Sequence: | 6; NC_000006.12 (73515750..73521032, complement) |
Tissue Specificity
Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus, nucleolus. Cell membrane. Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340). Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580). Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Ovarian Neoplasm
- Malignant Neoplasm Of Ovary
- Liver Carcinoma
- Hypertrophy
Interacting Proteins
- BBS1
- MDM2
- PCNA
- RAD23A
- SPHK1
- TTLL12
- YWHAZ
- ZBTB16
- ZDHHC17
Pathways
- Translation
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Reverse Transcription
- Localization
- Embryo Development
- Cell Cycle Arrest
- Drug Resistance
- Cell Death
- Cell Differentiation
- Oncogenesis
- Larval Development
PTMs
- Phosphorylation
- Cleavage
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EEF1A1
bosterbio.com/bosterbio-gene-info-cards/EEF1A1
References
PMID: 3512269 by Brands J.H.G.M., et al. The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites.
PMID: 2564392 by Uetsuki T., et al. Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha.